ArticleeLife2021
Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 56 citations in OpenAlex.
- Coupling between spatial compartments integrates morphogenetic patterning in the organ of Corti.PLoS biology · 2025Article
- The vertebrate segmentation clock drives segmentation by stabilizing Dusp phosphatases in zebrafish.Developmental cell · 2025Article
- Chemically defined and dynamic click hydrogels support hair cell differentiation in human inner ear organoids.Stem cell reports · 2025Article
- Wnt7b acts in concert with Wnt5a to regulate tissue elongation and planar cell polarity via noncanonical Wnt signaling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mechanochemical dynamics of collective cells and hierarchical topological defects in multicellular lumens.Science advances · 2024Article
- Modeling, applications and challenges of inner ear organoid.Smart medicine · 2024Review
- A guide to ERK dynamics, part 2: downstream decoding.The Biochemical journal · 2023Article
- Emerging roles and mechanisms of ERK pathway mechanosensing.Cellular and molecular life sciences : CMLS · 2023Review
- Conditional fluorescent mouse translocation reporters for ERK1/2 and AKT signaling.Developmental biology · 2023Article
- Independent control over cell patterning and adhesion on hydrogel substrates for tissue interface mechanobiology.iScience · 2023Article
- Precise alternating cellular pattern in the inner ear by coordinated hopping intercalations and delaminations.Science advances · 2023Article
- Advancements in inner ear development, regeneration, and repair through otic organoids.Current opinion in genetics & development · 2022Review
- Article
- Waves in Embryonic Development.Annual review of biophysics · 2022Review
- The mechanical forces that shape our senses.Development (Cambridge, England) · 2022Review
- Revealing epithelial morphogenetic mechanisms through live imaging.Current opinion in genetics & development · 2022Review
- Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development.The Biochemical journal · 2022Review
- Multiphoton intravital microscopy of rodents.Nature reviews. Methods primers · 2022Article
- Stalling interkinetic nuclear migration in curved pseudostratified epithelium of developing cochlea.Royal Society open science · 2021Article
- Mechanical forces shaping the development of the inner ear.Biophysical journal · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A notable example of spiral architecture in organs is the mammalian cochlear duct, where the morphology is critical for hearing function. Genetic studies have revealed necessary signaling molecules, but it remains unclear how cellular dynamics generate elongating, bending, and coiling of the cochlear duct. Here, we show that extracellular signal-regulated kinase (ERK) activation waves control collective cell migration during the murine cochlear duct development using deep tissue live-cell imaging, Förster resonance energy transfer (FRET)-based quantitation, and mathematical modeling. Long-term FRET imaging reveals that helical ERK activation propagates from the apex duct tip concomitant with the reverse multicellular flow on the lateral side of the developing cochlear duct, resulting in advection-based duct elongation. Moreover, model simulations, together with experiments, explain that the oscillatory wave trains of ERK activity and the cell flow are generated by mechanochemical feedback. Our findings propose a regulatory mechanism to coordinate the multicellular behaviors underlying the duct elongation during development.
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