ArticleeLife2021
Parabrachial opioidergic projections to preoptic hypothalamus mediate behavioral and physiological thermal defenses.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Thermal challenge and food intake: Mutual regulatory mechanisms.Neural regeneration research · 2026Article
- Article
- Parabrachial neurons orchestrate cold-induced homeostatic responses.Nature metabolism · 2026Article
- A Preoptic Neuronal Population Regulates Energy Expenditure and Balance.bioRxiv : the preprint server for biology · 2026Article
- Paraventricular nucleus-locus coeruleus VGlut2 neural circuit regulates energy metabolism in mice.Cell death & disease · 2025Article
- Behavioral and circuit principles of temperature gradient navigation.Current biology : CB · 2025Article
- Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- ParabrachialiScience · 2025Article
- Natural small molecule smart hydrogels inhibited the Hsp90/NF-κB signaling axis in inflammation to achieve sustained antipyretic effect.Journal of nanobiotechnology · 2025Article
- Article
- Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance.Nature neuroscience · 2025Article
- Inhibition of the hypothalamic ventromedial periventricular area activates a dynorphin pathway-dependent thermoregulatory inversion in rats.Current biology : CB · 2025Article
- Characterization of direct Purkinje cell outputs to the brainstem.bioRxiv : the preprint server for biology · 2024Article
- Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin EActa pharmacologica Sinica · 2024Article
- Hypothalamic Neuromodulation and Control of the Dermal Surface Temperature of Livestock during Hyperthermia.Animals : an open access journal from MDPI · 2024Review
- Glutamatergic supramammillary nucleus neurons respond to threatening stressors and promote active coping.eLife · 2024Article
- Article
- A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.Nature communications · 2024Article
- Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands.Nature reviews. Neuroscience · 2024Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Maintaining stable body temperature through environmental thermal stressors requires detection of temperature changes, relay of information, and coordination of physiological and behavioral responses. Studies have implicated areas in the preoptic area of the hypothalamus (POA) and the parabrachial nucleus (PBN) as nodes in the thermosensory neural circuitry and indicate that the opioid system within the POA is vital in regulating body temperature. In the present study we identify neurons projecting to the POA from PBN expressing the opioid peptides dynorphin and enkephalin. Using mouse models, we determine that warm-activated PBN neuronal populations overlap with both prodynorphin (Pdyn) and proenkephalin (Penk) expressing PBN populations. Here we report that in the PBN
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.