Evidence map›Paper›PMID 33666883›Full record

ArticleJournal of neurovirology2021

A comprehensive data-driven analysis framework for detecting impairments in brain function networks with resting state fMRI in HIV-infected individuals on cART.

Sheeba Arnold Anteraper, Kaundinya Gopinath, Michael J Hoch, Drenna Waldrop-Valverde, Donald Franklin, Scott L Letendre, Susan Whitfield-Gabrieli, Albert M Anderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sheeba Arnold Anteraper *Northeastern University, Boston, MA, USA.
Kaundinya Gopinath *Emory University School of Medicine, Atlanta, GA, USA.
Michael J HochEmory University School of Medicine, Atlanta, GA, USA.
Drenna Waldrop-ValverdeEmory University School of Nursing, Atlanta, GA, USA.
Donald FranklinUniversity of California At San Diego School of Medicine, La Jolla, San Diego, CA, USA.
Scott L LetendreUniversity of California At San Diego School of Medicine, La Jolla, San Diego, CA, USA.
Susan Whitfield-GabrieliNortheastern University, Boston, MA, USA.
Albert M AndersonEmory University School of Medicine, Atlanta, GA, USA. aande2@emory.edu.ORCID http://orcid.org/0000-0002-7216-9791

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
Detect: A novel device to assess how HIV affects neurocognitive decline and postural instability in older adults at risk for Alzheimer's DiseaseR01AG062387 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MOORE, RAEANNE CRISTINE · 2019 to 2023
$3.9M
Midcareer Investigator Award in Patient-Oriented NeuroAIDS ResearchK24MH097673 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LETENDRE, SCOTT L · 2013 to 2017
$917k
Study of zidovudine addition in HIV-associated neurocognitive disordersK23MH095679 · NIMH · EMORY UNIVERSITY · PI ANDERSON, ALBERT · 2013 to 2017
$899k
Viral immunocapture and isolation of virus from CSF lymphoid and myeloid cells to better understand HIV in the central nervous systemR21MH118092 · NIMH · EMORY UNIVERSITY · PI ANDERSON, ALBERT · 2018 to 2019
$437k
NIAID NIH HHS P30 AI050409NIA NIH HHS R01 AG062387NIMH NIH HHS K23 MH095679NIMH NIH HHS K24 MH097673NIMH NIH HHS P30 MH062512NIMH NIH HHS R21 MH118092
6 · The paper itself

Abstract

Central nervous system (CNS) sequelae continue to be common in HIV-infected individuals despite combination antiretroviral therapy (cART). These sequelae include HIV-associated neurocognitive disorder (HAND) and virologic persistence in the CNS. Resting state functional magnetic resonance imaging (rsfMRI) is a widely used tool to examine the integrity of brain function and pathology. In this study, we examined 16 HIV-positive (HIV+) subjects and 12 age, sex, and race matched HIV seronegative controls (HIV-) whole-brain high-resolution rsfMRI along with a battery of neurocognitive tests. A comprehensive data-driven analysis of rsfMRI revealed impaired functional connectivity, with very large effect sizes in executive function, language, and multisensory processing networks in HIV+ subjects. These results indicate the potential of high-resolution rsfMRI in combination with advanced data analysis techniques to yield biomarkers of neural impairment in HIV.

Indexed as

AdultAIDS Dementia ComplexBrainFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuroimagingRestbrain function networkscognitionexecutive functionfunctional connectivityhigh-resolutionHIVlanguagemulti-sensory perceptionmulti-voxel pattern analysisMVPAresting state fMRI

Identifiers

PMID33666883
PMCPMC12077813

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.