Trial reportMolecular and cellular biochemistry2021
Black chokeberry Aronia melanocarpa extract reduces blood pressure, glycemia and lipid profile in patients with metabolic syndrome: a prospective controlled trial.
Trial report in Molecular and cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Impact of a Chokeberry (Nutrients · 2025Pooled it
- Berry Dietary Interventions in Metabolic Syndrome: New Insights.Nutrients · 2023Pooled it
- Effects ofThe review of diabetic studies : RDS · 2022Pooled it
- Aronia Melanocarpa as a Multifunctional Superberry: From Antioxidant Potential to Therapeutic and Nanotechnological Applications.Current nutrition reports · 2026Review
- Polyphenols, Polysaccharides, and Their Complexes fromMolecules (Basel, Switzerland) · 2025Review
- Polyphenolic Compounds in the Prevention and Treatment of Hypertension: A Review.International journal of molecular sciences · 2025Review
- Exploration of Hypolipidemic Effects of Sterols fromFoods (Basel, Switzerland) · 2025Article
- Nutraceutical Potential of Anthocyanins: A Comprehensive Treatise.Food science & nutrition · 2025Review
- Green Extraction of Phenolic Compounds fromAntioxidants (Basel, Switzerland) · 2024Article
- Vasculo-Protective Effects of Standardized Black Chokeberry Extracts in Mice Aorta.International journal of molecular sciences · 2024Article
- The Role of Oxidative Stress and the Potential Therapeutic Benefits ofAntioxidants (Basel, Switzerland) · 2024Review
- Functional Activities and Mechanisms ofCurrent issues in molecular biology · 2024Review
- Consumption of Chokeberry Bio-Products Improves Specific Metabolic Parameters and Increases the Plasma Antioxidant Status.Antioxidants (Basel, Switzerland) · 2024Article
- Polyphenols mediated attenuation of diabetes associated cardiovascular complications: A comprehensive review.Journal of diabetes and metabolic disorders · 2024Review
- Review
- Article
- Anti-Diabetic Potential of Polyphenol-Rich Fruits from the Maleae Tribe-A Review of In Vitro and In Vivo Animal and Human Trials.Nutrients · 2023Review
- Review
- Redox Remodeling by Nutraceuticals for Prevention and Treatment of Acute and Chronic Inflammation.Antioxidants (Basel, Switzerland) · 2023Review
- Effects of Chokeberries (Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to examine the effect of 4-week supplementation of Alixir 400 PROTECT® (Standardized Aronia L. Melanocarpa Extract Extract-SAE) on clinical and biochemical parameters in patients with confirmed metabolic syndrome (MetS). This study was designed as a prospective open-label clinical case-series study with 28 days of follow-up with cases selected and followed during the period from February 1, 2018 to November 2019. The study included 143 male and female patients with MetS who were subjected to SAE. SAE supplementation significantly altered SP, BP as well as HR values. After 2 weeks, CHOL levels significantly decreased in the fMetS-DM group compared to the baseline values in this group, while the LDL levels significantly decreased in the fMetS group. Triglycerides significantly decreased only after 4 weeks of SAE treatment in diabetic groups of patients (fMetS-DM and mMetS-DM) compared to the baseline, while in non-diabetic groups this marker was not significantly altered. Increased polyphenols or SAE consumption is correlated with a positive effect on body weight, total cholesterol, low and high-density lipoproteins, blood pressure and glycemia. Increasing consumption of polyphenol-rich foods could be a promising strategy to reduce cardiovascular risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.