Evidence map›Paper›PMID 33666804›Full record

ArticleDoklady. Biochemistry and biophysics2021

Upconversion Nanoparticles Decorated with Polysialic Acid for Solid Tumors Visualization In Vivo.

P A Demina, N V Sholina, R A Akasov, D A Khochenkov, A V Nechaev, I V Balalaeva, E V Khaydukov, A N Generalova, S M Deev

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

P A DeminaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. polidemina1207@yandex.ru.
N V SholinaSechenov First Moscow State Medical University, Moscow, Russia.
R A AkasovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
D A KhochenkovBlokhin National Medical Research Center for Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
A V NechaevLomonosov Moscow State University of Fine Chemical Technologies, Moscow, Russia.
I V BalalaevaLobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
E V KhaydukovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
A N GeneralovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
S M DeevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Russian Academy of Sciences · RUInstitute of Bioorganic Chemistry · RULomonosov Moscow State University · RUMinistry of Health of the Russian Federation · RUN. I. Lobachevsky State University of Nizhny Novgorod · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upconversion nanoparticles (UCNPs) are a promising nanoplatform for bioreagent formation for in vivo imaging, which emit UV and blue light under the action of near-infrared radiation, providing deep tissue penetration and maintaining a high signal-to-noise ratio. In the case of solid tumor visualization, the UCNP surface functionalization is required to ensure a long circulation time, biocompatibility, and non-toxicity. The effective UCNP accumulation in the solid tumors is determined by the disturbed architecture of the vascular network and lymphatic drainage. This work demonstrates an approach to the UCNP biofunctionalization with endogenous polysialic acid for in vivo bioreagent formation. Bioreagents possess a low level of nonspecific protein adsorption and macrophage uptake, which allow the prolongation of the circulation time in the bloodstream up to 3 h. This leads to an intense photoluminescent signal in the tumor.

Indexed as

Cell Line, TumorHumansMolecular ImagingNanomedicineNanoparticlesSialic AcidsSignal-To-Noise RatioTissue Distributionpolysialic acidSialic Acidsbioimagingpolysialic acidsurface functionalizationupconversion nanophosphors

Identifiers

PMID33666804
PMCPMC8068683
OpenAlexW3135202496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.