Evidence map›Paper›PMID 33666770›Full record

SynthesisOral and maxillofacial surgery2021

Diagnostic and prognostic value of miRNAs on salivary gland tumors: a systematic review and meta-analysis.

Erison Santana Dos Santos, Ana Gabriela Costa Normando, João Figueira Scarini, Lívia Ramalho Crescencio, Reydson Alcides de Lima-Souza, Fernanda Viviane Mariano, Adriana Franco Paes Leme

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Oral and maxillofacial surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Erison Santana Dos SantosDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil. e228180@dac.unicamp.br.ORCID http://orcid.org/0000-0002-2088-1912
Ana Gabriela Costa NormandoDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-0307-4991
João Figueira ScariniDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-9015-6831
Lívia Ramalho CrescencioDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-7570-493X
Reydson Alcides de Lima-SouzaDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-5045-6960
Fernanda Viviane MarianoDepartment of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-3694-5025
Adriana Franco Paes LemeBrazilian Bioscience National Laboratory, The Brazilian Center for Research in Energy and Materials, Campina, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7959-147X
Universidade Estadual de Campinas (UNICAMP) · BRBrazilian Center for Research in Energy and Materials · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/07304-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/00831-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/19922-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/06809-2
6 · The paper itself

Abstract

purposeDifferent levels of miRNA expression have been described in salivary gland tumors as a potential diagnostic marker and predictor of survival. We systematically reviewed the literature to assess the diagnostic and prognostic value of miRNAs on salivary gland tumors.

methodsAn electronic search was conducted in PubMed, Scopus, Embase, Cochrane, and Web of Science databases. In the meta-analysis, we assumed random-effects model with adjusted hazard ratio (HR) and 95% confidence intervals (95% CI). For prognostic studies, the risk of bias was assessed by Meta-Analysis of Statistics Assessment and Review Instrument (MAStARI) and Quality Assessment Tool for Diagnostic Accuracy Studies-2 (QUADAS-2) was utilized for diagnostic studies.

resultsGathered data from 1.131 patients in seven studies demonstrated that different levels of miRNA expression presented diagnostic and prognostic in SGTs. The meta-analysis showed that altered miRNA expression were associated with shortened survival (HR, 2.35, 95% CI, 1.77-3.10, P < .00001). For diagnostic meta-analysis, the overall pooled results for specificity and sensibility were 0.87-0.97 (95% CI, 0.72-1) and 0.68-0.91 (95% CI, 0.51-0.96), respectively.

conclusionMicroRNAs may be useful in prognostication of patients with SGTs; however, the diagnostic value of miRNAs in SGTs is still limited.

Indexed as

MicroRNAsSalivary Gland NeoplasmsBiomarkers, TumorHumansPrognosisBiomarkers, TumorMicroRNAsMicroRNAsPrognosisSalivary gland neoplasmsSurvival ratesSystematic review

Identifiers

PMID33666770
OpenAlexW3135301134

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.