Evidence map›Paper›PMID 33666502›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Maternal systemic vascular dysfunction in a primate model of defective uterine spiral artery remodeling.

Eugene D Albrecht, Jeffery S Babischkin, Graham W Aberdeen, Marcia G Burch, Gerald J Pepe

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. The pathophysiology of pre-eclampsia.Nature reviews. Nephrology · 2026
    Review
  2. Review
  3. Article
  4. Vascular and autonomic function as early predictive biomarkers of the progression to gestational hypertension.European journal of obstetrics & gynecology and reproductive biology: X · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. B-flow/spatiotemporal image correlation M-mode: novel ultrasound method that detects decrease in spiral artery luminal diameter in first trimester in primate model of impaired spiral artery remodeling.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2022
    Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Eugene D AlbrechtDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland.ORCID 0000-0003-2827-9739
Jeffery S BabischkinDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland.
Graham W AberdeenDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland.
Marcia G BurchDepartment of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia.
Gerald J PepeDepartment of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia.
University of Maryland, Baltimore · USEastern Virginia Medical School · US

Funding

VEGF Gene Delivery In The Primate To Prevent Defective Spiral Artery Remodeling And Maternal Vascular DysfunctionR01HD093070 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI Graham W Aberdeen · 2017 to 2026
$5.1M
Estrogen Regulation of Fetal Microvessel Development During Primate Pregnancy: Impact on Insulin Sensitivity in OffspringR01DK120513 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI ALBRECHT, EUGENE D. · 2020 to 2024
$3.5M
HHS | National Institutes of Health (NIH) R01 DK 120 513HHS | National Institutes of Health (NIH) R01 HD 93070NICHD NIH HHS R01 HD093070
6 · The paper itself

Abstract

Uterine spiral artery remodeling (UAR) is essential for placental perfusion and fetal development. A defect in UAR underpins placental ischemia disorders, e.g., preeclampsia, that result in maternal systemic vascular endothelial dysfunction and hypertension. We have established a model of impaired UAR by prematurely elevating maternal serum estradiol levels during the first trimester of baboon pregnancy. However, it is unknown whether this experimental paradigm is associated with maternal vascular endothelial dysfunction. Therefore, in the present study baboons were administered estradiol on

Indexed as

Arterial PressureVascular RemodelingVasodilationAnimalsBrachial ArteryDisease Models, AnimalEstradiolFemaleGestational AgeHypertension, Pregnancy-InducedMicrovascular DensityMicrovesselsMuscle, SkeletalNitric OxideNitric Oxide Synthase Type IIIOxidative StressEstradiolestradiol 3-benzoateNitric OxideNitric Oxide Synthase Type IIIVascular Endothelial Growth Factor Receptor-1arteryprimateremodelinguterinevascular

Identifiers

PMID33666502
PMCPMC8260378
OpenAlexW3134762680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.