Evidence map›Paper›PMID 33666382›Full record

ArticleCanadian journal of surgery. Journal canadien de chirurgie2021

Effect of preoperative long-term opioid therapy on patient outcomes after total knee arthroplasty: an analysis of multicentre population-based administrative data.

C Michael Goplen, Sung Hyun Kang, Jason R Randell, C Allyson Jones, Donald C Voaklander, Thomas A Churchill, Lauren A Beaupre

Open access · diamondAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of surgery. Journal canadien de chirurgie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

C Michael GoplenFrom the Department of Surgery, University of Alberta, Edmonton, Alta. (Goplen, Beaupre, Churchill); the School of Public Health, University of Alberta, Edmonton, Alta. (Randell, Jones, Voaklander); the Department of Physical Therapy, University of Alberta, Edmonton, Alta. (Randell, Jones, Beaupre); and the Alberta Bone and Joint Institute, Calgary, Alta. (Kang).
Sung Hyun KangFrom the Department of Surgery, University of Alberta, Edmonton, Alta. (Goplen, Beaupre, Churchill); the School of Public Health, University of Alberta, Edmonton, Alta. (Randell, Jones, Voaklander); the Department of Physical Therapy, University of Alberta, Edmonton, Alta. (Randell, Jones, Beaupre); and the Alberta Bone and Joint Institute, Calgary, Alta. (Kang).
Jason R RandellFrom the Department of Surgery, University of Alberta, Edmonton, Alta. (Goplen, Beaupre, Churchill); the School of Public Health, University of Alberta, Edmonton, Alta. (Randell, Jones, Voaklander); the Department of Physical Therapy, University of Alberta, Edmonton, Alta. (Randell, Jones, Beaupre); and the Alberta Bone and Joint Institute, Calgary, Alta. (Kang).
C Allyson JonesFrom the Department of Surgery, University of Alberta, Edmonton, Alta. (Goplen, Beaupre, Churchill); the School of Public Health, University of Alberta, Edmonton, Alta. (Randell, Jones, Voaklander); the Department of Physical Therapy, University of Alberta, Edmonton, Alta. (Randell, Jones, Beaupre); and the Alberta Bone and Joint Institute, Calgary, Alta. (Kang).
Donald C VoaklanderFrom the Department of Surgery, University of Alberta, Edmonton, Alta. (Goplen, Beaupre, Churchill); the School of Public Health, University of Alberta, Edmonton, Alta. (Randell, Jones, Voaklander); the Department of Physical Therapy, University of Alberta, Edmonton, Alta. (Randell, Jones, Beaupre); and the Alberta Bone and Joint Institute, Calgary, Alta. (Kang).
Thomas A ChurchillFrom the Department of Surgery, University of Alberta, Edmonton, Alta. (Goplen, Beaupre, Churchill); the School of Public Health, University of Alberta, Edmonton, Alta. (Randell, Jones, Voaklander); the Department of Physical Therapy, University of Alberta, Edmonton, Alta. (Randell, Jones, Beaupre); and the Alberta Bone and Joint Institute, Calgary, Alta. (Kang).
Lauren A BeaupreFrom the Department of Surgery, University of Alberta, Edmonton, Alta. (Goplen, Beaupre, Churchill); the School of Public Health, University of Alberta, Edmonton, Alta. (Randell, Jones, Voaklander); the Department of Physical Therapy, University of Alberta, Edmonton, Alta. (Randell, Jones, Beaupre); and the Alberta Bone and Joint Institute, Calgary, Alta. (Kang).
University of Alberta · CAAlberta Bone and Joint Health Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Up to 40% of patients are receiving opioids at the time of total knee arthroplasty (TKA) in the United States despite evidence suggesting opioids are ineffective for pain associated with arthritis and have substantial risks. Our primary objective was to determine whether preoperative opioid users had worse knee pain and physical function outcomes 12 months after TKA than patients who were opioid-naive preoperatively; our secondary objective was to determine the prevalence of opioid use before and after TKA in Alberta, Canada. Methods: In this retrospective analysis of population-based data, we identified adult patients who underwent TKA between 2013 and 2015 in Alberta. We used multivariable linear regression to examine the association between preoperative opioid use and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and physical function scores 12 months after TKA, adjusting for potentially confounding variables. Results: Of the 1907 patients, 592 (31.0%) had at least 1 opioid dispensed before TKA, and 124 (6.5%) were classified as long-term opioid users. Long-term opioid users had worse adjusted WOMAC pain and physical function scores 12 months after TKA than patients who were opioid-naive preoperatively (pain score β = 7.7, 95% confidence interval [CI] 4.0 to 11.6; physical function score β = 7.8, 95% CI 4.0 to 11.6; p < 0.001 for both). The majority (89 ([71.8%]) of patients who were long-term opioid users preoperatively were dispensed opioids 180-360 days after TKA, compared to 158 (12.0%) patients who were opioid-naive preoperatively. Conclusion: A substantial number of patients were dispensed opioids before and after TKA, and patients who received opioids preoperatively had worse adjusted pain and functional outcome scores 12 months after TKA than patients who were opioidnaive preoperatively. These results suggest that patients prescribed opioids preoperatively should be counselled judiciously regarding expected outcomes after TKA.

Indexed as

Arthroplasty, Replacement, KneeKnee JointAgedAnalgesics, OpioidArthralgiaFemaleHumansMaleMiddle AgedOsteoarthritis, KneePreoperative PeriodRetrospective StudiesTime FactorsTreatment OutcomeUnited StatesAnalgesics, Opioid

Identifiers

PMID33666382
PMCPMC8064248
OpenAlexW3135694225

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.