ArticleMicrobial biotechnology2021
Revisiting a 'simple' fungal metabolic pathway reveals redundancy, complexity and diversity.
Article in Microbial biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Model-driven exploration of lactose and galactose metabolism via an oxidoreductive pathway in Sungouiella intermedia for cell factory applications.Microbial cell factories · 2026Article
- Genomic and physiological signatures of adaptation in pathogenic fungi.Nature communications · 2026Article
- The genome-scale sugar metabolic model fromCurrent research in microbial sciences · 2026Article
- L-Rhamnose Dehydrogenase LraA ofJournal of fungi (Basel, Switzerland) · 2025Article
- Black pepper essential oil nanoemulsion inhibitsFood science and biotechnology · 2025Article
- Dissecting the complex regulation of pentose utilization inCurrent research in microbial sciences · 2025Article
- Comparative transcriptome analyses and CRISPR/Cas9-mediated functional study ofFrontiers in microbiology · 2025Article
- Metabolic engineering reveals the relative importance of different sugar catabolic pathways during consumption of plant biomass byCurrent research in microbial sciences · 2025Article
- d-Xylitol Production from Sugar Beet Press Pulp Hydrolysate with EngineeredMicroorganisms · 2024Article
- Genome Mining Reveals a Surprising Number of Sugar Reductases inJournal of fungi (Basel, Switzerland) · 2023Article
- Non-canonical D-xylose and L-arabinose metabolism via D-arabitol in the oleaginous yeast Rhodosporidium toruloides.Microbial cell factories · 2023Article
- Identification of an l-Arabitol Transporter fromBiomolecules · 2023Article
- The Sugar Metabolic Model ofJournal of fungi (Basel, Switzerland) · 2022Article
- Revisiting a 'simple' fungal metabolic pathway reveals redundancy, complexity and diversity.Microbial biotechnology · 2021Article
- Characterization of d-xylose reductase, XyrB, fromBiotechnology reports (Amsterdam, Netherlands) · 2021Article
- Re-routing of Sugar Catabolism Provides a Better Insight Into Fungal Flexibility in Using Plant Biomass-Derived Monomers as Substrates.Frontiers in bioengineering and biotechnology · 2021Article
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Next to d-glucose, the pentoses l-arabinose and d-xylose are the main monosaccharide components of plant cell wall polysaccharides and are therefore of major importance in biotechnological applications that use plant biomass as a substrate. Pentose catabolism is one of the best-studied pathways of primary metabolism of Aspergillus niger, and an initial outline of this pathway with individual enzymes covering each step of the pathway has been previously established. However, although growth on l-arabinose and/or d-xylose of most pentose catabolic pathway (PCP) single deletion mutants of A. niger has been shown to be negatively affected, it was not abolished, suggesting the involvement of additional enzymes. Detailed analysis of the single deletion mutants of the known A. niger PCP genes led to the identification of additional genes involved in the pathway. These results reveal a high level of complexity and redundancy in this pathway, emphasizing the need for a comprehensive understanding of metabolic pathways before entering metabolic engineering of such pathways for the generation of more efficient fungal cell factories.
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