Evidence map›Paper›PMID 33666179›Full record

ArticleEndoscopic ultrasound

Preoperative EUS evaluation of the response to neoadjuvant therapy for gastric and esophagogastric junction cancer is correlated with survival: A single retrospective study of 97 patients.

Solène Hoibian, Marc Giovannini, Aurélie Autret, Christian Pesenti, Erwan Bories, Jean-Philippe Ratone, Yanis Dahel, Slimane Dermeche, Hélène Meillat, Jérôme Guiramand and 1 more

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In one paragraph

Article in Endoscopic ultrasound. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Solène HoibianDepartment of Endoscopy, Institut Paoli-Calmettes, Marseille, France.
Marc GiovanniniDepartment of Endoscopy, Institut Paoli-Calmettes, Marseille, France.
Aurélie AutretDepartment of Endoscopy, Institut Paoli-Calmettes, Marseille, France.
Christian PesentiDepartment of Endoscopy, Institut Paoli-Calmettes, Marseille, France.
Erwan BoriesDepartment of Endoscopy, Institut Paoli-Calmettes, Marseille, France.
Jean-Philippe RatoneDepartment of Endoscopy, Institut Paoli-Calmettes, Marseille, France.
Yanis DahelDepartment of Endoscopy, Institut Paoli-Calmettes, Marseille, France.
Slimane DermecheDepartment of Endoscopy, Institut Paoli-Calmettes, Marseille, France.
Hélène MeillatDepartment of Endoscopy, Institut Paoli-Calmettes, Marseille, France.
Jérôme GuiramandDepartment of Endoscopy, Institut Paoli-Calmettes, Marseille, France.
Fabrice CaillolDepartment of Endoscopy, Institut Paoli-Calmettes, Marseille, France.
Institut Paoli-Calmettes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe European Society for Medical Oncology suggests performing EUS staging for esophagogastric junction and gastric cancers to further assess the T and N stages. The use of EUS after neoadjuvant therapy (NT) is still under debate. We aimed to evaluate the contribution of EUS after NT to staging, therapeutic choices, and prognosis prediction. SUBJECTS AND

methodsIn 97 patients with esophagogastric junction and gastric cancers who received NT (chemotherapy or radiochemotherapy) followed by carcinologic surgery, EUS was performed before (uT, uN) and after (yuT, yuN) NT. We compared the results of EUS staging after NT (yuT and yuN) and final histology (ypT and ypN). We analyzed the correlation between overall survival (OS), disease-free survival (DFS), and the objective and subjective responses to NT evaluated by EUS (comparison of uT and yuT and uN and yuN with OS and DFS).

resultsEUS staging detected metastasis that went undetected by computed tomography in 16% of metastatic patients. The accuracy between EUS after NT and postoperative pathological findings was 44.4% (34.2%; 54.7%) for T stage and 49.3% (37.5%; 61.1%) for N stage. On multivariate analysis, OS had significantly correlated with the objective response to NT. In the case of a response to NT, the median OS was 64.77 months, and in the case of stable disease, the median OS was 22.9 months (P = 0.01).

conclusionEUS after NT can be used for staging. Despite its moderate accuracy, the evaluation of the response to NT by EUS seems to be correlated with patient prognosis.

Indexed as

esophagogastric junction cancerEUSgastric cancerneoadjuvant therapyprognosis

Identifiers

PMID33666179
PMCPMC8098840
OpenAlexW3134338221

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.