Evidence map›Paper›PMID 33666175›Full record

ArticleeLife2021

Systematic functional analysis of rab GTPases reveals limits of neuronal robustness to environmental challenges in flies.

Friederike E Kohrs, Ilsa-Maria Daumann, Bojana Pavlovic, Eugene Jennifer Jin, F Ridvan Kiral, Shih-Ching Lin, Filip Port, Heike Wolfenberg, Thomas F Mathejczyk, Gerit A Linneweber and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  6. Impairment of the Glial Phagolysosomal System Drives Prion-Like Propagation in aThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Lipid rafts, Rab GTPases, and a late endosomal checkpoint for plasma membrane recycling.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Organization of Presynaptic Autophagy-Related Processes.Frontiers in synaptic neuroscience · 2022
    Review
  19. Drosophila Rab39 Attenuates Lysosomal Degradation.International journal of molecular sciences · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Friederike E Kohrs *Division of Neurobiology, Institute for Biology, Freie Universität Berlin, Berlin, Germany.
Ilsa-Maria Daumann *Division of Neurobiology, Institute for Biology, Freie Universität Berlin, Berlin, Germany.
Bojana PavlovicGerman Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics and Heidelberg University, Heidelberg, Germany.
Eugene Jennifer JinDivision of Neurobiology, Institute for Biology, Freie Universität Berlin, Berlin, Germany.
F Ridvan KiralDivision of Neurobiology, Institute for Biology, Freie Universität Berlin, Berlin, Germany.
Shih-Ching LinNational Taiwan University, Taipei, Taiwan.ORCID 0000-0003-2960-5348
Filip PortGerman Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics and Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-5157-4835
Heike WolfenbergDivision of Neurobiology, Institute for Biology, Freie Universität Berlin, Berlin, Germany.
Thomas F MathejczykDivision of Neurobiology, Institute for Biology, Freie Universität Berlin, Berlin, Germany.
Gerit A LinneweberDivision of Neurobiology, Institute for Biology, Freie Universität Berlin, Berlin, Germany.
Chih-Chiang ChanNational Taiwan University, Taipei, Taiwan.ORCID 0000-0003-2626-3805
Michael BoutrosGerman Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics and Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-9458-817X
P Robin HiesingerDivision of Neurobiology, Institute for Biology, Freie Universität Berlin, Berlin, Germany.ORCID 0000-0003-4698-3527
Freie Universität Berlin · DEGerman Cancer Research Center · DENational Taiwan University · TWUniversity of California San Diego · USYale University · US

Funding

Regulation of Synaptic Specificity in the Visual System by Intracellular TraffickR01EY018884 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI HIESINGER, PETER ROBIN · 2008 to 2018
$3.6M
NEI NIH HHS R01 EY018884
6 · The paper itself

Abstract

Rab GTPases are molecular switches that regulate membrane trafficking in all cells. Neurons have particular demands on membrane trafficking and express numerous Rab GTPases of unknown function. Here, we report the generation and characterization of molecularly defined null mutants for all 26

Indexed as

AnimalsDrosophila melanogasterDrosophila ProteinsGene Knock-In TechniquesImidazolesNeuronsrab GTP-Binding ProteinsTemperatureDrosophila ProteinsImidazolesmutaprodenafilrab GTP-Binding Proteinscell biologyD. melanogasterDrosophilamutant collectionneuroscienceRab GTPase

Identifiers

PMID33666175
PMCPMC8016483
OpenAlexW3135860616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.