Evidence map›Paper›PMID 33666136›Full record

ReviewRNA biology2021

Recent advances in the regulation of plant miRNA biogenesis.

Mu Li, Bin Yu

Open access · bronzeAbstract readReview
In one paragraph

Review in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
24.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.

  1. What Do We Know about Barley miRNAs?International journal of molecular sciences · 2022
    Pooled it
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  17. Article
  18. In Vitro Transcription of Plant miRNA for Structural and Processing Analysis.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  19. The PpPep2-Triggered PTI-like Response in Peach Trees Is Mediated by miRNAs.International journal of molecular sciences · 2024
    Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mu LiSchool of Biological Sciences & Center for Plant Science Innovation University of Nebraska-Lincoln, Lincoln, Nebraska USA.
Bin YuSchool of Biological Sciences & Center for Plant Science Innovation University of Nebraska-Lincoln, Lincoln, Nebraska USA.
University of Nebraska–Lincoln · US

Funding

Understand the function of the MOS4-associated complex in microRNA biogenesisR01GM127414 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI YU, BIN · 2018 to 2022
$1.6M
NIGMS NIH HHS R01 GM127414
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are essential non-coding riboregulators of gene expression in plants and animals. In plants, miRNAs guide their effector protein named ARGONAUTE (AGO) to find target RNAs for gene silencing through target RNA cleavage or translational inhibition. miRNAs are derived from primary miRNA transcripts (pri-miRNAs), most of which are transcribed by the DNA-dependent RNA polymerase II. In plants, an RNase III enzyme DICER-LIKE1-containing complex processes pri-miRNAs in the nucleus into miRNAs. To ensure proper function of miRNAs, plants use multiple mechanisms to control miRNA accumulation. On one hand, pri-miRNA levels are controlled through transcription and stability. On the other hand, the activities of the DCL1 complex are regulated by many protein factors at transcriptional, post-transcriptional and post-translational levels. Notably, recent studies reveal that pri-miRNA structure/sequence features and modifications also play important roles in miRNA biogenesis. In this review, we summarize recent progresses on the mechanisms regulating miRNA biogenesis.

Indexed as

Argonaute ProteinsGene Expression Regulation, PlantMicroRNAsPlant ProteinsPlantsRibonuclease IIIRNA, PlantArgonaute ProteinsMicroRNAsPlant ProteinsRibonuclease IIIRNA, Plantdcl1Plant miRNA biogenesispri-miRNA processingpri-miRNA stabilitypri-miRNA transcription

Identifiers

PMID33666136
PMCPMC8632083
OpenAlexW3133524502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.