ArticleJACC. Basic to translational science2021
Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities.
Article in JACC. Basic to translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- Acoustic Cardiography Captures Stress-Dependent Ventricular Dysfunction and Distinguishes Heart Failure Phenotypes in a Porcine Model.Biomedicines · 2026Article
- Integrated Myocardial and Plasma Lipidome Across the Human Obesity-Heart Failure Spectrum.Research square · 2026Article
- Excitation-contraction coupling, cardiomyocyte electrophysiology, and transcriptome profiles in two HFpEF murine models: etiology and sex-dependent differences.American journal of physiology. Heart and circulatory physiology · 2026Article
- Central Adiposity or Hypertension: Which Drives Heart Failure With a Preserved Ejection Fraction?Journal of the American College of Cardiology · 2025Review
- What Is Cardiometabolic HFpEF and How Can We Study it Preclinically?JACC. Basic to translational science · 2025Review
- Renal denervation improves cardiac function and exercise duration in a miniswine model of heart failure with preserved ejection fraction.European journal of heart failure · 2025Article
- Ultrasound Renal Denervation Attenuates Early Cardiac Remodeling After Acute Myocardial Infarction in a Swine Model of Hypertensions and Dyslipidemia: A Pilot Study.Clinical and translational science · 2025Article
- A new model of heart failure with preserved ejection fraction induced by metabolic syndrome in Ossabaw miniature swine.Basic research in cardiology · 2025Article
- Sexual dimorphism in animal models of heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Development of a whole-exome sequencing kit to facilitate porcine biomedical research.Genome biology · 2025Article
- Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise.Journal of cardiovascular translational research · 2025Review
- Cardiometabolic Phenotype in HFpEF: Insights from Murine Models.Biomedicines · 2025Review
- Comprehensive echocardiographic protocol for pigs with emphasis on diastolic function: advantages over MRI assessment.American journal of physiology. Heart and circulatory physiology · 2025Article
- Cardiomyocyte myofilament function in common animal models of heart failure with preserved ejection fraction.Journal of molecular and cellular cardiology · 2024Article
- Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2024Article
- Characterization of a novel ovine model of hypertensive heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2024Article
- Myocardial Inflammation in Heart Failure With Reduced and Preserved Ejection Fraction.Circulation research · 2024Review
- In the heart and beyond: Mitochondrial dysfunction in heart failure with preserved ejection fraction (HFpEF).Current opinion in pharmacology · 2024Review
- The pig as an optimal animal model for cardiovascular research.Lab animal · 2024Review
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
A lack of preclinical large animal models of heart failure with preserved ejection fraction (HFpEF) that recapitulate this comorbid-laden syndrome has led to the inability to tease out mechanistic insights and to test novel therapeutic strategies. This study developed a large animal model that integrated multiple comorbid determinants of HFpEF in a miniswine breed that exhibited sensitivity to obesity, metabolic syndrome, and vascular disease with overt clinical signs of heart failure. The combination of a Western diet and 11-deoxycorticosterone acetate salt-induced hypertension in the Göttingen miniswine led to the development of a novel large animal model of HFpEF that exhibited multiorgan involvement and a full spectrum of comorbidities associated with human HFpEF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.