Evidence map›Paper›PMID 33665507›Full record

ArticleBioactive materials2021

Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration.

Lei Fan, Pengfei Guan, Cairong Xiao, Huiquan Wen, Qiyou Wang, Can Liu, Yian Luo, Limin Ma, Guoxin Tan, Peng Yu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 152 citations in OpenAlex.

  1. Article
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  7. Advanced small extracellular vesicles delivery systems forExtracellular vesicles and circulating nucleic acids · 2026
    Review
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  10. Anatomical implant region - a critical determinant for the osteogenic potency of small extracellular vesicles and rhBMP-2.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Article
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  15. Article
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  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Lei FanSchool of Materials Science and Engineering & National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510641, China.
Pengfei GuanDepartment of Spine Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.
Cairong XiaoSchool of Materials Science and Engineering & National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510641, China.
Huiquan WenDepartment of Radiology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.
Qiyou WangDepartment of Spine Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.
Can LiuDepartment of Spine Surgery, the First Hospital of Zhejiang University, Hangzhou, 310003, China.
Yian LuoSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006, China.
Limin MaDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Guoxin TanSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006, China.
Peng YuSchool of Materials Science and Engineering & National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510641, China.
Lei ZhouSchool of Materials Science and Engineering & National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510641, China.
Chengyun NingSchool of Materials Science and Engineering & National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510641, China.
South China University of Technology · CNGuangdong University of Technology · CNSun Yat-sen University · CNFirst Affiliated Hospital Zhejiang University · CNGuangdong Provincial People's Hospital · CNSouthern Medical University · CNThird Affiliated Hospital of Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The host immune response effecting on biomaterials is critical to determine implant fates and bone regeneration property. Bone marrow stem cells (BMSCs) derived exosomes (Exos) contain multiple biosignal molecules and have been demonstrated to exhibit immunomodulatory functions. Herein, we develop a BMSC-derived Exos-functionalized implant to accelerate bone integration by immunoregulation. BMSC-derived Exos were reversibly incorporated on tannic acid (TA) modified sulfonated polyetheretherketone (SPEEK) via the strong interaction of TA with biomacromolecules. The slowly released Exos from SPEEK can be phagocytosed by co-cultured cells, which could efficiently improve the biocompatibilities of SPEEK.

Indexed as

BMSC-Derived exosomesBone regenerationMacrophages polarizationOsteoimmunologyPolyetheretherketone

Identifiers

PMID33665507
PMCPMC7897935
OpenAlexW3133645251

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.