ArticleSynthetic and systems biotechnology2021
Disaccharide phosphorylases: Structure, catalytic mechanisms and directed evolution.
Article in Synthetic and systems biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Regioselective Glycosylation of Fluorine-18-Labeled Sorbitol for Enhanced Bacterial Detection In Vivo Using PET.JACS Au · 2025Article
- The many functions of carbohydrate-active enzymes in family GH65: diversity and application.Applied microbiology and biotechnology · 2024Review
- Elucidation of bacterial trehalose-degrading trehalase and trehalose phosphorylase: physiological significance and its potential applications.Glycobiology · 2024Review
- Evolution of Phosphorylase Activity in an Ancestral Glycosyltransferase.ACS catalysis · 2024Article
- Chemoenzymatic Syntheses of Fluorine-18-Labeled Disaccharides from [Journal of the American Chemical Society · 2023Article
- Energetics of the Glycosyl Transfer Reactions of Sucrose Phosphorylase.Biochemistry · 2023Article
- Inoculation withFrontiers in microbiology · 2023Article
- Editorial for "Biointelligent manufacturing in Memorium of Arnold (Arny) L. Demain".Synthetic and systems biotechnology · 2022Article
- Discovery of a Kojibiose Hydrolase by Analysis of Specificity-Determining Correlated Positions in Glycoside Hydrolase Family 65.Molecules (Basel, Switzerland) · 2021Article
- Recent advances in enzymatic synthesis of β-glucan and cellulose.Carbohydrate research · 2021Review
- Boosted activity by engineering the enzyme microenvironment in cascade reaction: A molecular understanding.Synthetic and systems biotechnology · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disaccharide phosphorylases (DSPs) are carbohydrate-active enzymes with outstanding potential for the biocatalytic conversion of common table sugar into products with attractive properties. They are modular enzymes that form active homo-oligomers. From a mechanistic as well as a structural point of view, they are similar to glycoside hydrolases or glycosyltransferases. As the majority of DSPs show strict stereo- and regiospecificities, these enzymes were used to synthesize specific disaccharides. Currently, protein engineering of DSPs is pursued in different laboratories to broaden the donor and acceptor substrate specificities or improve the industrial particularity of naturally existing enzymes, to eventually generate a toolbox of new catalysts for glycoside synthesis. Herein we review the characteristics and classifications of reported DSPs and the glycoside products that they have been used to synthesize.
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