ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Trial
- Language impairments in behavioural variant frontotemporal dementia: a comparative study with semantic dementia.Journal of neurology · 2026Article
- Rethinking anomia across the frontotemporal dementia spectrum: marker of language dysfunction or global cognitive decline?medRxiv : the preprint server for health sciences · 2026Article
- Your Mileage May Vary: Individuals with Primary Progressive Aphasia Differ Widely in Their Utilization of Congruent Prosodic and Visual Information During Sentence Comprehension.Brain sciences · 2026Article
- From "invisible" to "audible": Features extracted during simple speech tasks classify patient-reported fatigue in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Decision making in frontotemporal dementia: neuropsychological and neuroimaging assessments.Frontiers in neuroscience · 2025Review
- Evaluation of Differential Diagnostics Potential of Uniform Data Set 2 Neuropsychology Battery Using Alzheimer's Disease Biomarkers.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Development and validation of a nonverbal consensus-based semantic memory paradigm in patients with epilepsy.Journal of the International Neuropsychological Society : JINS · 2024Article
- Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum.Brain : a journal of neurology · 2024Article
- Discriminating nonfluent/agrammatic and logopenic PPA variants with automatically extracted morphosyntactic measures from connected speech.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Assessment of Language Function in Older Mandarin-Speaking Adults with Mild Cognitive Impairment using Multifaceted Language Tests.Journal of Alzheimer's disease : JAD · 2024Article
- Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Language impairment in the genetic forms of behavioural variant frontotemporal dementia.Journal of neurology · 2023Article
- A syntax-lexicon trade-off in language production.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Auditory Verb Generation Performance Patterns Dissociate Variants of Primary Progressive Aphasia.Frontiers in psychology · 2022Article
- Task performance to discriminate among variants of primary progressive aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Differential linguistic features of verbal fluency in behavioral variant frontotemporal dementia and primary progressive aphasia.Applied neuropsychology. AdultArticle
- Article
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 1 country.
Funding
Abstract
introductionThe Frontotemporal Lobar Degeneration Module (FTLD-MOD) includes a neuropsychological battery designed to assess the clinical features of FTLD, although much is unknown about its utility. We investigated FTLD-MOD and Uniform Data Set 3.0 (UDS) language tests for differential diagnosis and disease monitoring.
methodsLinear regressions compared baseline performances in 1655 National Alzheimer's Coordinating Center participants (behavioral variant frontotemporal dementia (bvFTD, n = 612), semantic variant primary progressive aphasia (svPPA, n = 168), non-fluent/agrammatic variant PPA (nfvPPA, n = 168), logopenic variant PPA (lvPPA, n = 109), and controls (n = 581)). Sample sizes to detect treatment effects were estimated using longitudinal data.
resultsAmong PPAs, the FTLD-MOD language tasks and UDS Multilingual Naming Test accurately discriminated svPPA. Number Span Forward best discriminated lvPPA; Phonemic:Semantic Fluency ratio was excellent for nfvPPA classification. UDS fluency and naming measures required the smallest sample size to detect meaningful change. DISCUSSION: The FTLD-MOD and UDS differentiated among PPA subtypes. UDS 3.0 measures performed best for longitudinal monitoring.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.