ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Blood neurofilament light in remote settings: Alternative protocols to support sample collection in challenging pre-analytical conditions.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Blood-based biomarkers of Alzheimer's disease: potential utility in clinical practice.Current opinion in neurology · 2026Review
- Clinical translation of fluid, imaging, and digital biomarkers for Alzheimer's disease.Alzheimer's research & therapy · 2026Review
- Reinventing "N" in the A/T/N framework: The case for digital.The journal of prevention of Alzheimer's disease · 2025Article
- Markers of axonal injury in blood and tissue triggered by acute and chronic demyelination.Brain : a journal of neurology · 2025Article
- Delirium pathophysiology in cancer: neurofilament light chain biomarker - narrative review.BMJ supportive & palliative care · 2025Review
- Evidence that minocycline treatment confounds the interpretation of neurofilament as a biomarker.Brain communications · 2025Article
- Overview of Alzheimer's Disease Neuroimaging Initiative and future clinical trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting.Molecular neurodegeneration · 2024Review
- Biomarkers of Alzheimer's disease and neurodegeneration in dried blood spots-A new collection method for remote settings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Quantification of neurofilament light and glial fibrillary acidic protein in finger-prick blood.Brain communications · 2024Article
- Combining impact monitoring mouthguards and blood biomarkers to monitor head impacts among Muay Thai athletes - A case study.JSAMS plus · 2023Article
- Diagnostic challenges for dementia in Australia: are blood-based biomarkers the solution?Internal medicine journal · 2022Article
- Characterization of pre-analytical sample handling effects on a panel of Alzheimer's disease-related blood-based biomarkers: Results from the Standardization of Alzheimer's Blood Biomarkers (SABB) working group.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Brain Injury Biomarkers for Predicting Outcome After Cardiac Arrest.Critical care (London, England) · 2022Review
- Blood Tests for Alzheimer's Disease: Increasing Efforts to Expand and Diversify Research Participation Is Critical for Widespread Validation and Acceptance.Journal of Alzheimer's disease : JAD · 2022Article
- Establishment of reference values for plasma neurofilament light based on healthy individuals aged 5-90 years.Brain communications · 2022Article
- Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease.Journal of internal medicine · 2021Review
- Blood Biomarkers for Alzheimer's Disease in Down Syndrome.Journal of clinical medicine · 2021Review
- Blood neurofilament light in remote settings: Alternative protocols to support sample collection in challenging pre-analytical conditions.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study investigated alternative pre-analytical handling of blood for neurofilament light (NfL) analysis where resources are limited.
methodPlasma NfL was measured with single molecule array after alternative blood processing procedures: dried plasma spots (DPS), dried blood spots (DBS), and delayed 48-hour centrifugation. These were compared to standardized plasma processing (reference standard [RS]). In a discovery cohort (n = 10) and a confirmatory cohort (n = 21), whole blood was obtained from individuals with unknown clinical etiology. In the confirmatory cohort, delayed centrifugation protocol was paired with either 37°C incubation or sample shaking to test the effect of these parameters.
resultsDelayed centrifugation (R DISCUSSION: DPS or delayed centrifugation are viable pre-analytical procedures for the accurate quantification of plasma NfL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.