Evidence map›Paper›PMID 33664997›Full record

ArticleMolecular therapy. Nucleic acids2021

Osteoclast-derived small extracellular vesicles induce osteogenic differentiation via inhibiting ARHGAP1.

Mengmeng Liang, Xiaofan Yin, Shuai Zhang, Hongbo Ai, Fei Luo, Jianzhong Xu, Ce Dou, Shiwu Dong, Qinyu Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mengmeng LiangDepartment of Biomedical Materials Science, Third Military Medical University, Chongqing 400038, China.
Xiaofan YinCollege of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730000, China.
Shuai ZhangDepartment of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Hongbo AiDepartment of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Fei LuoDepartment of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Jianzhong XuDepartment of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Ce DouDepartment of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Shiwu DongDepartment of Biomedical Materials Science, Third Military Medical University, Chongqing 400038, China.
Qinyu MaDepartment of Biomedical Materials Science, Third Military Medical University, Chongqing 400038, China.
Army Medical University · CNLanzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activated osteoclasts release large amounts of small extracellular vesicles (sEVs) during bone remodeling. However, little is known about whether osteoclast-derived sEVs affect surrounding cells. In this study, osteoclasts were generated by stimulating bone marrow macrophages (BMMs) with macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear actor κB ligand (RANKL). We performed microarray analysis of sEV-microRNAs (miRNAs)s secreted from osteoclast at different stages and identified four miRNAs that were highly expressed in mature osteoclast-derived sEVs. One of these miRNAs, miR-324, significantly induced osteogenic differentiation and mineralization of primary mesenchymal stem cells (MSCs)

Indexed as

extracellular vesiclesosteoclastosteogenic differentiation

Identifiers

PMID33664997
PMCPMC7900016
OpenAlexW3126888099

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.