ArticleNeuro-oncology practice2021
Exploring sleep disturbance among adults with primary or secondary malignant brain tumors and their caregivers.
Article in Neuro-oncology practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Proposal for Managing Cancer-Related Insomnia: A Systematic Literature Review of Associated Factors and a Narrative Review of Treatment.Cancer medicine · 2024Pooled it
- Telehealth group Cognitive-Behavioral Therapy for Insomnia (CBT-I) in primary brain tumor: Primary outcomes from a single-arm phase II feasibility and proof-of-concept trial.Neuro-oncology · 2024Trial
- Review
- Well-being and coping: Key aspects of unmet need of people living with glioma.Neuro-oncology practice · 2025Article
- Circadian rhythm related genes signature in glioma for drug resistance prediction: a comprehensive analysis integrating transcriptomics and machine learning.Discover oncology · 2025Article
- Social Determinants of Health Predict Sleep-Wake Disturbances Among Patients Living With Primary Brain Tumors: A Cross-Sectional Analysis.Cancer medicine · 2025Article
- Sleep disturbances in brain tumors: a narrative review.Frontiers in oncology · 2025Review
- Study protocol for Cognitive Behavioral Therapy for Insomnia in patients with primary brain tumor: A single-arm phase 2a proof-of-concept trial.Contemporary clinical trials communications · 2023Article
- Update on Prevalence of Pain in Patients with Cancer 2022: A Systematic Literature Review and Meta-Analysis.Cancers · 2023Review
- Impact of Preoperative Sleep Disturbances on Postoperative Delirium in Patients with Intracranial Tumors: A Prospective, Observational, Cohort Study.Nature and science of sleep · 2023Article
- Exploring the prevalence and burden of sleep disturbance in primary brain tumor patients.Neuro-oncology practice · 2022Article
- Sleep disturbance in cancer patients referred to an ambulatory integrative oncology consultation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Prevalence, correlates, and impact of sleep disturbance in Chinese meningioma patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Study of the Economic, Environmental, and Social Factors Affecting Chinese Residents' Health Based on Machine Learning.Frontiers in public health · 2022Article
- Understanding sleep disturbance in the context of malignant brain tumors: a qualitative analysis.Neuro-oncology practice · 2021Article
- Nationally recruited telehealth group-based Cognitive Behavioral Therapy for Insomnia in patients with primary brain tumors: A randomized NIH ORBIT Phase IIc study.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmerging evidence supports the clinical impact of sleep disturbance (SD) on cancer patients. This study aimed to determine the prevalence and predictors of SD in people with malignant brain tumors and caregivers, and explore any relationship between the patient-caregiver dyad's sleep.
methodsEighty-one adults with primary malignant (91%) or metastatic (9%) brain tumors and their family caregivers (n = 44) completed a series of self-report questionnaires, including the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index, and the drowsiness item of The MD Anderson Symptom Inventory-Brain Tumor in an Australian ambulatory neuro-oncology setting. Participants were grouped by the PSQI cutoff (SD > 5), and binary logistic regression analyses were performed to identify risk factors.
resultsOf patients, 53% reported SD and 15% of those clinically significant insomnia, and 27% reported moderate to severe daytime drowsiness. Whereas anxiety, depression, fatigue, pain, neurocognitive symptoms, and antiemetic use were higher in patients with SD, fatigue and KPS were strong predictors of SD. In caregivers, 55% reported poor sleep and 13% clinical insomnia. Anxiety, caregiver burden, and comorbid illness were significantly associated with caregivers' SD. The individual's SD did not affect the chance of the other member of the patient-caregiver dyad experiencing SD.
conclusionsMore than half the sample had sleep disturbance, which was linked to many concomitant symptoms, such as fatigue in patients and anxiety in caregivers, potentially contributing to distress and functional impairment. Understanding underlying mechanisms of SD, the potential use of these clinical predictors in care settings, and options for management is warranted.
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