Evidence map›Paper›PMID 33664968›Full record

ArticleNeuro-oncology practice2021

Predictors of early, recurrent, and intractable seizures in low-grade glioma.

Jasmin Jo, Kathryn Nevel, Ryan Sutyla, Mark Smolkin, M Beatriz Lopes, David Schiff

Open access · bronzeAbstract read
In one paragraph

Article in Neuro-oncology practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
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  7. Article
  8. Review
  9. Article
  10. Elevated glioma-related cortical glutamateBrain communications · 2025
    Article
  11. Article
  12. IDH mutant high-grade gliomas.Frontiers in molecular neuroscience · 2025
    Review
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  14. Article
  15. Review
  16. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jasmin JoDepartment of Neurology, University of Virginia, Charlottesville, Virginia.ORCID https://orcid.org/0000-0003-3679-1206
Kathryn NevelDepartment of Neurology, University of Virginia, Charlottesville, Virginia.
Ryan SutylaSchool of Medicine, University of Virginia, Charlottesville, Virginia.
Mark SmolkinDepartment of Public Health Sciences, Division of Biostatistics, University of Virginia, Charlottesville, Virginia.
M Beatriz LopesDepartment of Pathology, Division of Neuropathology, University of Virginia, Charlottesville, Virginia.
David SchiffDepartment of Neurology, Division of Neuro-Oncology, University of Virginia, Charlottesville, Virginia.
University of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeizures are common among patients with low-grade glioma (LGG) and can significantly affect morbidity. We sought to determine the association between the clinical and molecular factors with seizure incidence and refractoriness in LGG patients.

methodsWe conducted a retrospective review at the University of Virginia in patients with LGG (World Health Organization, WHO Grade II) evaluated between 2002 and 2015. Descriptive statistics were calculated for variables of interest, and the Kaplan-Meier method was used to estimate survival curves, which were compared with the log-rank test.

resultsA total of 291 patients were included; 254 had molecular testing performed for presence of an isocitrate dehydrogenase (

conclusionsSeizures are common among patients with LGG. Differences in preoperative or postoperative and intractable seizure rates by WHO 2016 classification were not detected. Our data showed a trend toward higher seizure incidence preoperatively in patients with

Indexed as

IDH mutationlow-grade gliomaseizureWHO 2016 classification

Identifiers

PMID33664968
PMCPMC7906271
OpenAlexW3081758358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.