Evidence map›Paper›PMID 33664888›Full record

ArticleJournal of arrhythmia2021

Changes in plasma concentrations of edoxaban and coagulation biomarkers according to thromboembolic risk and atrial fibrillation type in patients undergoing catheter ablation: Subanalysis of KYU-RABLE.

Tetsuji Shinohara, Naohiko Takahashi, Yasushi Mukai, Tetsuya Kimura, Keita Yamaguchi, Atsushi Takita, Hideki Origasa, Ken Okumura, KYU‐RABLE Investigators

Open access · goldAbstract read
In one paragraph

Article in Journal of arrhythmia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Tetsuji ShinoharaDepartment of Cardiology and Clinical Examination Faculty of Medicine Oita University Oita Japan.ORCID https://orcid.org/0000-0002-6106-6017
Naohiko TakahashiDepartment of Cardiology and Clinical Examination Faculty of Medicine Oita University Oita Japan.ORCID https://orcid.org/0000-0001-9037-0010
Yasushi MukaiCardiology Division Japanese Red Cross Fukuoka Hospital Fukuoka Japan.ORCID https://orcid.org/0000-0002-0275-7280
Tetsuya KimuraMedical Science Department Daiichi Sankyo Co., Ltd Tokyo Japan.
Keita YamaguchiMedical Science Department Daiichi Sankyo Co., Ltd Tokyo Japan.
Atsushi TakitaData Intelligence Department Daiichi Sankyo Co., Ltd Tokyo Japan.
Hideki OrigasaDivision of Biostatistics and Clinical Epidemiology University of Toyama Graduate School of Medicine and Pharmaceutical Sciences Toyama Japan.
Ken OkumuraDivision of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center Kumamoto Japan.ORCID https://orcid.org/0000-0002-3202-7203
KYU‐RABLE Investigators
Daiichi Sankyo (Germany) · DEOita University · JPDaiichi-Sankyo (Japan) · JPJapanese Red Cross Fukuoka Hospital · JPSaiseikai Kumamoto Hospital · JPUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCatheter ablation (CA) for atrial fibrillation (AF) can be associated with a risk of thromboembolism and bleeding. We recently demonstrated that uninterrupted edoxaban with one dose delayed on the CA procedural day is associated with a low risk of periprocedural complications. Previous reports have indicated that some specific subgroups of patients undergoing CA have an increased risk of bleeding and thromboembolic complications. This subanalysis of the KYU-RABLE study assessed the changes in plasma concentrations of edoxaban and coagulation biomarkers during the periprocedural period of CA in subgroups stratified by the risk of thromboembolism assessed by CHADS

methodsWe evaluated changes in plasma concentrations of edoxaban and coagulation biomarkers (D-dimer and prothrombin fragment F1+2), by subgroup, during the periprocedural period of CA. Measurements were made prior to CA (procedure day).

resultsThis subanalysis evaluated data from 343 patients with CHADS

conclusionsThe changes in plasma concentrations of edoxaban and coagulation biomarkers in each subgroup were similar to those of the whole analysis, regardless of the thromboembolic risk (CHADS

Indexed as

atrial fibrillationcatheter ablationedoxabanhemorrhagethromboembolism

Identifiers

PMID33664888
PMCPMC7896453
OpenAlexW3114394394

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.