ArticleTheranostics2021
Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis.
Open access · goldAbstract read
In one paragraph
Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 45 citations in OpenAlex.
- Identification of PGF+ endothelial cells associated with plaque instability in carotid atherosclerosis by scRNA-seq and RNA-seq analysis.Cell cycle (Georgetown, Tex.) · 2026Article
- 10,11-Dehydrocurvularin attenuates LPS-induced neuroinflammation in BV2 cells by inhibiting the TLR2/MyD88/NLRP3 signaling pathway.Biochemistry and biophysics reports · 2026Article
- Emerging roles of granzymes in neurodegeneration and neuroinflammation: mechanistic insights and therapeutic opportunities.Acta neuropathologica · 2026Review
- Cytokine-mediated, organ-specific immune modulation and dysregulation of innate lymphocytes in sepsis.Seminars in immunopathology · 2026Review
- Anti-polymyositis/scleroderma antibody-positive myositis exhibits greater cutaneous T cell activation than anti-ARS antibody-positive myositis.JAAD international · 2026Article
- Mechanism of Gzma-mediated GEF-H1 activation in intestinal epithelial cells leading to intestinal barrier dysfunction in sepsis.Clinical and translational medicine · 2026Article
- Circulating granzyme A is elevated within the dysregulated host response and associates with mortality in abdominal sepsis.Frontiers in immunology · 2026Article
- Dynamic changes of natural killer cell immunophenotypes and receptors according to the mortality in the intra-abdominal murine sepsis model.Intensive care medicine experimental · 2025Article
- Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025Review
- Physical activity affects DNA methylation-derived inflammation markers in a community-based Parkinson's disease study.Brain, behavior, & immunity - health · 2025Article
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- Editorial: Roles of granzymes in inflammation, aging, and autoimmunity.Frontiers in immunology · 2025Article
- Decoding monocyte heterogeneity in sepsis: a single-cell apoptotic signature for immune stratification and guiding precision therapy.Frontiers in pharmacology · 2025Article
- Enhancing natural killer cell anti-tumour activity through macrophage manipulation.Frontiers in immunology · 2025Review
- Distinct cell death pathways induced by granzymes collectively protect against intestinal Salmonella infection.Mucosal immunology · 2024Article
- Effect of acute exercise on gene expression in peripheral blood mononuclear cells of puberty children.Scientific reports · 2024Article
- Key role for inflammation-related signaling in the pathogenesis of myopia based on evidence from proteomics analysis.Scientific reports · 2024Article
- Granzyme serine proteases in inflammation and rheumatic diseases.Nature reviews. Rheumatology · 2024Review
- Selective Detection of Active Extracellular Granzyme A by Using a Novel Fluorescent Immunoprobe with Application to Inflammatory Diseases.ACS pharmacology & translational science · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 2 institutions in 2 countries.
Marcela Garzón-TituañaFundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain.
José L Sierra-MonzónFundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain.
Laura ComasInstituto de Carboquímica ICB-CSIC, 50018, Zaragoza, Spain.
Llipsy SantiagoFundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain.
Tatiana Khaliulina-UshakovaFundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain.
Iratxe Uranga-MurilloFundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain.
Ariel Ramirez-LabradaFundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain.
Elena TapiaAnimal Unit, University of Zaragoza, 50009, Zaragoza, Spain.
Elena Morte-RomeaFundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain.
Sonia AlgarateFundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain.
Ludovic CoutyINSERM U970, Paris Cardiovascular Research Centre, Université de Paris, 75015, Paris, France.
Eric CamererINSERM U970, Paris Cardiovascular Research Centre, Université de Paris, 75015, Paris, France.
Phillip I BirdDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, 3800, Clayton VIC, Australia.
Cristina SeralFundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain.
Pilar LuqueFundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain.
José R Paño-PardoFundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain.
Eva M GalvezInstituto de Carboquímica ICB-CSIC, 50018, Zaragoza, Spain.
Julián PardoFundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), 50009, Zaragoza, Spain.
Maykel AriasInstituto de Carboquímica ICB-CSIC, 50018, Zaragoza, Spain.
Instituto de Carboquímica · ESParis Cardiovascular Research Center · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
AgedAged, 80 and overAnimalsCytokinesDisease Models, AnimalFemaleGranzymesHumansInflammation MediatorsInterleukin-6Killer Cells, NaturalMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutCytokinesgranzyme A, mouseGranzymesGZMA protein, humanIL6 protein, humanInflammation MediatorsInterleukin-6Serpinb6b protein, mouseSerpinsTlr4 protein, mouseToll-Like Receptor 4cecal ligation and puncture.Granzyme Ainflammationperitonitissepsis
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.