Evidence map›Paper›PMID 33664856›Full record

ArticleTheranostics2021

Polysaccharide mycophenolate-based nanoparticles for enhanced immunosuppression and treatment of immune-mediated inflammatory diseases.

Yuce Li, Yuchen Lou, Yu Chen, Jing Yang, Danqi Li, Biling Jiang, Jiajia Lan, Jingjing Wen, Yangxue Fu, Yamin Zhang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yuce LiKey Laboratory of Material Chemistry for Energy Conversion and Storage (HUST) of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, China.
Yuchen LouDepartment of Dermatology, Union Hospital, Tongji Medical College, HUST, Wuhan 430022, China.
Yu ChenKey Laboratory of Material Chemistry for Energy Conversion and Storage (HUST) of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, China.
Jing YangDepartment of Dermatology, Union Hospital, Tongji Medical College, HUST, Wuhan 430022, China.
Danqi LiDepartment of Dermatology, Union Hospital, Tongji Medical College, HUST, Wuhan 430022, China.
Biling JiangDepartment of Dermatology, Union Hospital, Tongji Medical College, HUST, Wuhan 430022, China.
Jiajia LanDepartment of Dermatology, Union Hospital, Tongji Medical College, HUST, Wuhan 430022, China.
Jingjing WenDepartment of Dermatology, Union Hospital, Tongji Medical College, HUST, Wuhan 430022, China.
Yangxue FuDepartment of Dermatology, Union Hospital, Tongji Medical College, HUST, Wuhan 430022, China.
Yamin ZhangDepartment of Dermatology, Union Hospital, Tongji Medical College, HUST, Wuhan 430022, China.
Juan TaoDepartment of Dermatology, Union Hospital, Tongji Medical College, HUST, Wuhan 430022, China.
Jintao ZhuKey Laboratory of Material Chemistry for Energy Conversion and Storage (HUST) of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, China.
Union Hospital · CNHuazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune-mediated inflammatory diseases (IMIDs) are characterized by immune dysregulation and severe inflammation caused by the aberrant and overactive host immunological response. Mycophenolic acid (MPA)-based immunosuppressive drugs are potential treatments for IMIDs because of their mild side-effect profile; however, their therapeutic effects are limited by the high albumin binding rate, unsatisfactory pharmacokinetics, and undefined cellular uptake selectivity.

Indexed as

AnimalsDendritic CellsDisease Models, AnimalDrug Delivery SystemsFemaleHumansImmunosuppression TherapyImmunosuppressive AgentsInflammationMaterials TestingMiceMice, Inbred BALB CMycophenolic AcidNanoparticlesPolysaccharidesPrecision MedicineImmunosuppressive AgentsMycophenolic AcidPolysaccharidesimmune-mediated inflammatory diseasesimmunosuppressionmycophenolatepolysaccharidepsoriasis

Identifiers

PMID33664856
PMCPMC7914372
OpenAlexW3126358774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.