ArticleEvolutionary applications2021
Transcriptional frontloading contributes to cross-tolerance between stressors.
Article in Evolutionary applications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Neighboring Gulf Killifish (Ecology and evolution · 2026Article
- With a Little Help From Their Friends: Endolithic Microbial Communities Modulate Mussel Survival, Behaviour and Molecular Responses Under Thermal Stress.Molecular ecology · 2026Article
- Gene-to-Population Level Responses to Multiple Stressors on the Rocky Shore.Ecology and evolution · 2026Article
- Trematode infection buffers heat stress in blue mussels Mytilus edulis: The role of heat shock proteins.The Journal of animal ecology · 2026Article
- Heat exposure improves acute copper tolerance in the intertidal copepod Tigriopus californicus.Environmental science and pollution research international · 2026Article
- Cross-generational plasticity in Atlantic silversides (Menidia menidia) under the combined effects of hypoxia and acidification.The Journal of experimental biology · 2025Article
- Synthesis of transcriptomic studies reveals a core response to heat stress in abalone (genus Haliotis).BMC genomics · 2025Article
- Heat Stress, Starvation, and Heat Stress Plus Starvation Cause Unique Transcriptomic Responses in the Economically Important Red AbalonemicroPublication biology · 2025Article
- Protective multi-stressor interactions in the Anthropocene: Key considerations for investigating cross-tolerance in a conservation context.Conservation physiology · 2025Article
- Genet identity and season drive gene expression in outplanted Acropora palmata at different reef sites.Scientific reports · 2024Article
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- Examination of gammarid transcriptomes reveals a widespread occurrence of key metabolic genes from epibiont bdelloid rotifers in freshwater species.Open biology · 2023Article
- The environmental cellular stress response: the intertidal as a multistressor model.Cell stress & chaperones · 2023Review
- Resistance ofFrontiers in immunology · 2023Article
- Cross-protection interactions in insect pests: Implications for pest management in a changing climate.Pest management science · 2023Review
- Article
- Transcriptional frontloading contributes to cross-tolerance between stressors.Evolutionary applications · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adaptive value of phenotypic plasticity for performance under single stressors is well documented. However, plasticity may only truly be adaptive in the natural multifactorial environment if it confers resilience to stressors of a different nature, a phenomenon known as cross-tolerance. An understanding of the mechanistic basis of cross-tolerance is essential to aid prediction of species resilience to future environmental change. Here, we identified mechanisms underpinning cross-tolerance between two stressors predicted to increasingly challenge aquatic ecosystems under climate change, chronic warming and hypoxia, in an ecologically-important aquatic invertebrate. Warm acclimation improved hypoxic performance through an adaptive hypometabolic strategy and changes in the expression of hundreds of genes that are important in the response to hypoxia. These 'frontloaded' genes showed a reduced reaction to hypoxia in the warm acclimated compared to the cold acclimated group. Frontloaded genes included stress indicators, immune response and protein synthesis genes that are protective at the cellular level. We conclude that increased constitutive gene expression as a result of warm acclimation reduced the requirement for inducible stress responses to hypoxia. We propose that transcriptional frontloading contributes to cross-tolerance between stressors and may promote fitness of organisms in environments increasingly challenged by multiple anthropogenic threats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.