Evidence map›Paper›PMID 33664682›Full record

ArticleFrontiers in psychiatry2021

A 7 Tesla Amygdalar-Hippocampal Shape Analysis of Lithium Response in Bipolar Disorder.

Thomas L Athey, Can Ceritoglu, Daniel J Tward, Kwame S Kutten, J Raymond DePaulo, Kara Glazer, Fernando S Goes, John R Kelsoe, Francis Mondimore, Caroline M Nievergelt and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Thomas L AtheyCenter for Imaging Science, Johns Hopkins University, Baltimore, MD, United States.
Can CeritogluCenter for Imaging Science, Johns Hopkins University, Baltimore, MD, United States.
Daniel J TwardCenter for Imaging Science, Johns Hopkins University, Baltimore, MD, United States.
Kwame S KuttenCenter for Imaging Science, Johns Hopkins University, Baltimore, MD, United States.
J Raymond DePauloDepartment of Psychiatry and Behavioral Science, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Kara GlazerDepartment of Occupational Therapy, Boston University, Boston, MA, United States.
Fernando S GoesDepartment of Psychiatry and Behavioral Science, Johns Hopkins School of Medicine, Baltimore, MD, United States.
John R KelsoeDepartment of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, United States.
Francis MondimoreDepartment of Psychiatry and Behavioral Science, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Caroline M NievergeltDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Kelly Rootes-MurdyDepartment of Psychology, Georgia State University, Atlanta, GA, United States.
Peter P ZandiDepartment of Psychiatry and Behavioral Science, Johns Hopkins School of Medicine, Baltimore, MD, United States.
J Tilak RatnanatherCenter for Imaging Science, Johns Hopkins University, Baltimore, MD, United States.
Pamela B MahonDepartment of Psychiatry and Behavioral Science, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Johns Hopkins University · USBoston University · USGeorgia State University · USHarvard University · USUniversity of California, San Diego · USVA San Diego Healthcare System · US

Funding

TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Pharmacogenomics of Mood Stabilizer Response in Bipolar DisorderU01MH092758 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 2010 to 2014
$6.2M
Neurodegenerative and Neurodevelopmental Subcortical Shape DiffeomorphometryR01EB020062 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI MILLER, MICHAEL I, MOSTOFSKY, STEWART H · 2016 to 2019
$2.8M
Oxidative Stress and Bipolar Disorder TrajectoriesR01MH110797 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAHON, PAMELA BELMONTE · 2016 to 2021
$2.6M
Neuroimaging and Genetic Biomarkers of Lithium Response in Bipolar DisorderK01MH093870 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MAHON, PAMELA BELMONTE · 2012 to 2015
$714k
NIBIB NIH HHS P41 EB015909NIBIB NIH HHS R01 EB020062NIMH NIH HHS K01 MH093870NIMH NIH HHS R01 MH110797NIMH NIH HHS U01 MH092758
6 · The paper itself

Abstract

Research to discover clinically useful predictors of lithium response in patients with bipolar disorder has largely found them to be elusive. We demonstrate here that detailed neuroimaging may have the potential to fill this important gap in mood disorder therapeutics. Lithium treatment and bipolar disorder have both been shown to affect anatomy of the hippocampi and amygdalae but there is no consensus on the nature of their effects. We aimed to investigate structural surface anatomy changes in amygdala and hippocampus correlated with treatment response in bipolar disorder. Patients with bipolar disorder (

Indexed as

7T MRIamygdalabipolar disorderhippocampuslithiumshape analysis

Identifiers

PMID33664682
PMCPMC7920967
OpenAlexW3129298279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.