ArticleFrontiers in human neuroscience2021
Altered Frequency-Dependent Brain Activation and White Matter Integrity Associated With Cognition in Characterizing Preclinical Alzheimer's Disease Stages.
Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Subjective cognitive decline and objective cognitive performance in older adults: A systematic review of longitudinal and cross-sectional studies.Journal of neuropsychology · 2025Pooled it
- Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- Individualized prediction of transition from subjective cognitive decline to mild cognitive impairment based on multimodal MRI: a 10-year follow-up study.The journal of prevention of Alzheimer's disease · 2026Article
- Subtype-Specific Brain Atrophy and White Matter Alterations in Mild Cognitive Impairment.Brain sciences · 2025Article
- Structural brain correlates of neuropsychomotor performance in older adults with early cognitive decline.World journal of psychiatry · 2025Article
- Link of gray matter volume to cognitive and motor function in elderly patients with mild cognitive impairment.World journal of psychiatry · 2025Article
- Dynamic and Static Structure-Function Coupling With Machine Learning for the Early Detection of Alzheimer's Disease.Human brain mapping · 2025Article
- Differential Abnormality in Regional Brain Spontaneous Activity and Functional Connectivity in Patients of Non-Acute Subcortical Stroke With Versus Without Global Cognitive Functional Impairment.Brain and behavior · 2025Article
- Exploring the potential central regulatory mechanisms of acupuncture for acute-stage Bell's palsy: an fMRI-based investigation.Frontiers in neuroscience · 2025Article
- Abnormal neural network connectivity in heart failure with reduced and mild-ranged ejection fraction patients: an independent component and dynamic functional network connectivity analysis.Frontiers in neurology · 2025Article
- Research progress on brain network imaging biomarkers of subjective cognitive decline.Frontiers in neuroscience · 2025Review
- Local Neuronal Activity and the Hippocampal Functional Network Can Predict the Recovery of Consciousness in Individuals With Acute Disorders of Consciousness Caused by Neurological Injury.CNS neuroscience & therapeutics · 2024Article
- Diffusion imaging markers of accelerated aging of the lower cingulum in subjective cognitive decline.Frontiers in neurology · 2024Article
- Investigating the spontaneous brain activities of patients with subjective cognitive decline and mild cognitive impairment: an amplitude of low-frequency fluctuation functional magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2023Article
- Functional and structural alterations of dorsal attention network in preclinical and early-stage Alzheimer's disease.CNS neuroscience & therapeutics · 2023Article
- Shared alterations in hippocampal structural covariance in subjective cognitive decline and migraine.Frontiers in aging neuroscience · 2023Article
- Shared and specific dynamics of brain activity and connectivity in amnestic and nonamnestic mild cognitive impairment.CNS neuroscience & therapeutics · 2022Article
- Concurrent Structural and Functional Patterns in Patients With Amnestic Mild Cognitive Impairment.Frontiers in aging neuroscience · 2022Article
- Reduced Inter-Voxel White Matter Integrity in Subjective Cognitive Decline: Diffusion Tensor Imaging With Tract-Based Spatial Statistics Analysis.Frontiers in aging neuroscience · 2022Article
- Functional Integrity of Executive Control Network Contributed to Retained Executive Abilities in Mild Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubjective cognitive decline (SCD), non-amnestic mild cognitive impairment (naMCI), and amnestic mild cognitive impairment (aMCI) are regarded to be at high risk of converting to Alzheimer's disease (AD). Amplitude of low-frequency fluctuations (ALFF) can reflect functional deterioration while diffusion tensor imaging (DTI) is capable of detecting white matter integrity. Our study aimed to investigate the structural and functional alterations to further reveal convergence and divergence among SCD, naMCI, and aMCI and how these contribute to cognitive deterioration.
methodsWe analyzed ALFF under slow-4 (0.027-0.073 Hz) and slow-5 (0.01-0.027 Hz) bands and white matter fiber integrity among normal controls (CN), SCD, naMCI, and aMCI groups. Correlation analyses were further utilized among paired DTI alteration, ALFF deterioration, and cognitive decline.
resultsFor ALFF calculation, ascended ALFF values were detected in the lingual gyrus (LING) and superior frontal gyrus (SFG) within SCD and naMCI patients, respectively. Descended ALFF values were presented mainly in the LING, SFG, middle frontal gyrus, and precuneus in aMCI patients compared to CN, SCD, and naMCI groups. For DTI analyses, white matter alterations were detected within the uncinate fasciculus (UF) in aMCI patients and within the superior longitudinal fasciculus (SLF) in naMCI patients. SCD patients presented alterations in both fasciculi. Correlation analyses revealed that the majority of these structural and functional alterations were associated with complicated cognitive decline. Besides, UF alterations were correlated with ALFF deterioration in the SFG within aMCI patients.
conclusionsSCD shares structurally and functionally deteriorative characteristics with aMCI and naMCI, and tends to convert to either of them. Furthermore, abnormalities in white matter fibers may be the structural basis of abnormal brain activation in preclinical AD stages. Combined together, it suggests that structural and functional integration may characterize the preclinical AD progression.
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