Evidence map›Paper›PMID 33664644›Full record

ArticleFrontiers in neuroscience2021

Effects of Alzheimer's and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer's Disease.

Wha Jin Lee, Cindy W Yoon, Sung-Woo Kim, Hye Jin Jeong, Seongho Seo, Duk L Na, Young Noh, Joon-Kyung Seong

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Wha Jin LeeSchool of Biomedical Engineering, Korea University, Seoul, South Korea.
Cindy W YoonDepartment of Neurology, School of Medicine, Inha University, Incheon, South Korea.
Sung-Woo KimSchool of Biomedical Engineering, Korea University, Seoul, South Korea.
Hye Jin JeongNeuroscience Research Institute, Gachon University, Incheon, South Korea.
Seongho SeoDepartment of Neuroscience, College of Medicine, Gachon University, Incheon, South Korea.
Duk L NaDepartment of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea.
Young NohDepartment of Neurology, Gil Medical Center, College of Medicine, Gachon University, Incheon, South Korea.
Joon-Kyung SeongSchool of Biomedical Engineering, Korea University, Seoul, South Korea.
Gachon University · KRKorea University · KRInha University · KRSungkyunkwan University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early- and late-onset Alzheimer's disease (AD) patients often exhibit distinct features. We sought to compare overall white matter connectivity and evaluate the pathological factors (amyloid, tau, and vascular pathologies) that affect the disruption of connectivity in these two groups. A total of 50 early- and 38 late-onset AD patients, as well as age-matched cognitively normal participants, were enrolled and underwent diffusion-weighted magnetic resonance imaging to construct fractional anisotropy-weighted white matter connectivity maps. [

Indexed as

amyloidearly-onset ADlate-onset ADpositron emission tomographysmall vessel diseasetauwhite matter connectivity

Identifiers

PMID33664644
PMCPMC7921324
OpenAlexW3131363704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.