Evidence map›Paper›PMID 33664643›Full record

ArticleFrontiers in neuroscience2021

Auditory Stimulation Modulates Resting-State Functional Connectivity in Unresponsive Wakefulness Syndrome Patients.

Melanie Boltzmann, Simone B Schmidt, Christoph Gutenbrunner, Joachim K Krauss, Martin Stangel, Günter U Höglinger, Claus-W Wallesch, Thomas F Münte, Jens D Rollnik

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Specific Rhythm Auditory Stimulation for Attention: A Pilot Randomized Controlled Trial.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Article
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Melanie BoltzmannBDH-Klinik Hessisch Oldendorf, Hessisch Oldendorf, Germany.
Simone B SchmidtBDH-Klinik Hessisch Oldendorf, Hessisch Oldendorf, Germany.
Christoph GutenbrunnerClinic for Rehabilitation Medicine, Hannover Medical School, Hannover, Germany.
Joachim K KraussDepartment of Neurosurgery, Hannover Medical School, Hannover, Germany.
Martin StangelDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Günter U HöglingerDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Claus-W WalleschBDH-Klinik Elzach, Elzach, Germany.
Thomas F MünteDepartment of Neurology, University of Lübeck, Lübeck, Germany.
Jens D RollnikBDH-Klinik Hessisch Oldendorf, Hessisch Oldendorf, Germany.
Medizinische Hochschule Hannover · DEBDH-Klinik Hessisch Oldendorf · DEBDH-Klinik Elzach · DEUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Passive listening to music is associated with several psychological and physical benefits in both, healthy and diseased populations. In this fMRI study, we examined whether preferred music has effects on the functional connectivity within resting-state networks related to consciousness. Thirteen patients in unresponsive wakefulness syndrome (UWS) and 18 healthy controls (HC) were enrolled. Both groups were exposed to different auditory stimulation (scanner noise, preferred music, and aversive auditory stimulation). Functional connectivity was analyzed using a seed-based approach. In HC, no differences were found between the three conditions, indicating that their networks are already working at high level. UWS patients showed impaired functional connectivity within all resting-state networks. In addition, functional connectivity of the auditory network was modulated by preferred music and aversive auditory stimulation. Hence, both conditions have the potential to modulate brain activity of UWS patients.

Indexed as

auditory stimulationdisorders of consciousnessneurological early rehabilitationresting-state fMRIunresponsive wakefulness syndrome

Identifiers

PMID33664643
PMCPMC7921457
OpenAlexW3132163177

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.