ArticleNature immunology2021
Wnt-β-catenin activation epigenetically reprograms T
Open access · greenAbstract read
In one paragraph
Article in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- T-bet: biological functions, molecular mechanisms, and therapeutic applications: a systematic review.Frontiers in immunology · 2026Pooled it
- From signals to systems: the epigenetic-microbiome-mitochondrial axis in IBD pathogenesis.Gut microbes · 2026Review
- TIF1γ regulates stability of regulatory T cells during inflammation.Nature immunology · 2026Article
- TIF1γ holds the line against regulatory T cell plasticity.Nature immunology · 2026Article
- Pathophysiology of colitis-associated colorectal cancer.Nature reviews. Gastroenterology & hepatology · 2026Review
- Local and circulating cytotoxic CD4medRxiv : the preprint server for health sciences · 2026Article
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- Unlocking Wnt's weak spot: Glycosylated nanoalbumins to reignite immune responses in MSS-CRC.Journal of pharmaceutical analysis · 2026Article
- Next-Generation regulatory T cell therapies: Translational considerations for inflammatory bowel disease.Human immunology · 2026Review
- CLOCK is an Epigenetic Integrator of Circadian Rhythm and T Cell Immunity.Research square · 2026Article
- REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis.The Journal of experimental medicine · 2026Article
- Epigenetic Landscapes in Ulcerative Colitis: From Mechanistic Insights to Clinical Translation.ACS omega · 2025Review
- Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential.Signal transduction and targeted therapy · 2025Review
- Generation of Regulatory T Cells From Human Memory CD4European journal of immunology · 2025Article
- Therapeutic Potential of Polyphenols in Targeting Th17/Treg Balance for Intestinal Barrier Maintenance.Food science & nutrition · 2025Review
- Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances.Signal transduction and targeted therapy · 2025Review
- Tripartite Motif Containing 71 Suppresses Tumor Growth by Down-Regulating eIF5A2 Expression in Laryngeal Squamous Cell Carcinoma.Applied biochemistry and biotechnology · 2025Article
- Tumor-derived colorectal cancer organoids induce a unique Treg cell population by directing CD4iScience · 2025Article
- Inhibition of the Wnt/β‑catenin signaling pathway and SOX9 by XAV939 did not alleviate inflammation in a dextran sulfate sodium‑induced ulcerative colitis model.Experimental and therapeutic medicine · 2025Article
- Emerging role of small RNAs in inflammatory bowel disease and associated colorectal cancer (Review).International journal of molecular medicine · 2025Review
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Jasmin QuandtKnapp Research Center, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Stephen ArnovitzKnapp Research Center, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5307-8694
Leila HaghiKnapp Research Center, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Janine WoehlkKnapp Research Center, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Azam MohsinKnapp Research Center, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Michael OkoreehKnapp Research Center, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Priya S MathurKnapp Research Center, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Akinola Olumide EmmanuelKnapp Research Center, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Abu OsmanDepartments of Immunology and Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.
Manisha KrishnanKnapp Research Center, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Samuel B MorinSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Alexander T PearsonSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Randy F SweisSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-0497-9637
Joel PekowSection of Gastroenterology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Christopher R WeberDepartment of Pathology, University of Chicago, Chicago, IL, USA.
Khashayarsha KhazaieDepartments of Immunology and Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA. khazaie@mayo.edu.
Fotini GounariKnapp Research Center, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA. fgounari@uchicago.edu.ORCID http://orcid.org/0000-0003-2936-066X
University of Chicago · USMayo Clinic · US
Funding
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8MRESEARCH TRAINING IN RESPIRATORY BIOLOGYT32HL007605 · NHLBI · UNIVERSITY OF CHICAGO · PI Yun Fang, Gokhan M. Mutlu · 1985 to 2026
$18.1MRuth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)T32HD007009 · NICHD · UNIVERSITY OF CHICAGO · PI NANCY B SCHWARTZ · 1985 to 2026
$13.0MINTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7MMulti-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5MHow beta-catenin expands Foxp3+RORgammat+ Pro-inflammatoryT-regulatory cells - RenewalR01AI108682 · NIAID · UNIVERSITY OF CHICAGO · PI GOUNARI, FOTINI, KHAZAIE, KHASHAYARSHA · 2014 to 2024
$5.1MEpigenetic mechanisms of carcinogenesis by Parvimonas micra, an oral cavity commensal turned colon cancer pathogenR01CA264048 · NCI · MAYO CLINIC ARIZONA · PI BOARDMAN, LISA ALLYN, GOUNARI, FOTINI · 2021 to 2025
$3.1MMolecular functions of Tcf-1 in DP thymocytesR01AI147652 · NIAID · UNIVERSITY OF CHICAGO · PI GOUNARI, FOTINI · 2020 to 2024
$2.0MProinflammatory T Regulatory Cells in Colon CancerR01CA160436 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KHAZAIE, KHASHAYARSHA · 2012 to 2017
$2.0MWnt/b-catenin signaling in T-cell transformationR21AI076720 · NIAID · UNIVERSITY OF CHICAGO · PI GOUNARI, FOTINI · 2008 to 2009
$422kNCI NIH HHS R01 CA160436NCI NIH HHS R01 CA264048NCI NIH HHS T32 CA009594NHLBI NIH HHS T32 HL007605NIAID NIH HHS R01 AI108682NIAID NIH HHS R01 AI147652NIAID NIH HHS R21 AI076720NIAID NIH HHS T32 AI007090NICHD NIH HHS T32 HD007009NIDDK NIH HHS P30 DK042086
Abstract
The diversity of regulatory T (T
Indexed as
Cell ProliferationCellular ReprogrammingEpigenesis, GeneticLymphocyte ActivationWnt Signaling PathwayAnimalsCase-Control StudiesCells, CulturedColitis-Associated NeoplasmsColitis, UlcerativeCrohn DiseaseCytokinesDisease Models, AnimalForkhead Transcription FactorsGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 1-alphaCytokinesForkhead Transcription FactorsFOXP3 protein, humanFoxp3 protein, mouseHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseNuclear Receptor Subfamily 1, Group F, Member 3RORC protein, humanRorc protein, mouseT Cell Transcription Factor 1TCF7 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.