Evidence map›Paper›PMID 33664453›Full record

ArticleOncogene2021

BCDIN3D RNA methyltransferase stimulates Aldolase C expression and glycolysis through let-7 microRNA in breast cancer cells.

Calder W Reinsborough, Hélène Ipas, Nathan S Abell, Ellen B Gouws, J Paige Williams, Marvin Mercado, Carla Van Den Berg, Blerta Xhemalçe

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Biomedicines · 2021
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Calder W Reinsborough *Department of Molecular Biosciences, LiveStrong Cancer Institute at Dell Medical School, University of Texas at Austin, 2500 Speedway, Austin, TX, 78712, USA.
Hélène Ipas *Department of Molecular Biosciences, LiveStrong Cancer Institute at Dell Medical School, University of Texas at Austin, 2500 Speedway, Austin, TX, 78712, USA.
Nathan S Abell *Department of Molecular Biosciences, LiveStrong Cancer Institute at Dell Medical School, University of Texas at Austin, 2500 Speedway, Austin, TX, 78712, USA.
Ellen B GouwsDepartment of Molecular Biosciences, LiveStrong Cancer Institute at Dell Medical School, University of Texas at Austin, 2500 Speedway, Austin, TX, 78712, USA.
J Paige WilliamsDepartment of Molecular Biosciences, LiveStrong Cancer Institute at Dell Medical School, University of Texas at Austin, 2500 Speedway, Austin, TX, 78712, USA.
Marvin MercadoDepartment of Molecular Biosciences, LiveStrong Cancer Institute at Dell Medical School, University of Texas at Austin, 2500 Speedway, Austin, TX, 78712, USA.
Carla Van Den BergDivision of Pharmacology & Toxicology, College of Pharmacy, and Department of Oncology, University of Texas at Austin, Dell Medical School, Austin, TX, 78723, USA.
Blerta XhemalçeDepartment of Molecular Biosciences, LiveStrong Cancer Institute at Dell Medical School, University of Texas at Austin, 2500 Speedway, Austin, TX, 78712, USA. b.xhemalce@austin.utexas.edu.ORCID http://orcid.org/0000-0002-0517-9607
Livestrong Foundation · USThe University of Texas at Austin · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Elucidating mechanisms of microRNA pathway deregulation in human cellsR01GM127802 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI XHEMALCE, BLERTA · 2018 to 2022
$1.7M
NCI NIH HHS P30 CA016672NIGMS NIH HHS R01 GM127802
6 · The paper itself

Abstract

Type II diabetes (T2D) and specific cancers share many risk factors, however, the molecular mechanisms underlying these connections are often not well-understood. BCDIN3D is an RNA modifying enzyme that methylates specific precursor microRNAs and tRNA

Indexed as

Breast NeoplasmsDiabetes Mellitus, Type 2FemaleFructose-Bisphosphate AldolaseGene Expression Regulation, NeoplasticGlycolysisHeterograftsHumansMCF-7 CellsMetabolomeMethyltransferasesMicroRNAsObesityProteomeRisk FactorsTranscriptomeBCDIN3D protein, humanFructose-Bisphosphate AldolaseMethyltransferasesMicroRNAsmirnlet7 microRNA, humanProteome

Identifiers

PMID33664453
PMCPMC8026734
OpenAlexW3133645656

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.