Evidence map›Paper›PMID 33664426›Full record

ArticleScientific reports2021

A retrospective study of clinical and laboratory features and treatment on cats highly suspected of feline infectious peritonitis in Wuhan, China.

Yiya Yin, Ting Li, Chaohao Wang, Xiaoya Liu, Hehao Ouyang, Wanfeng Ji, Jiahao Liu, Xueyu Liao, Junyi Li, Changmin Hu

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 58 citations in OpenAlex.

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  8. Immunomodulatory Effects ofInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yiya YinCollege of Veterinary Medicine, Huazhong Agricultural University, Rm 321 Vet. Teaching Hospital BLDG, No.1 Shizishan St., Hongshan District, Wuhan City, 430070, Hubei Province, China.
Ting LiCollege of Veterinary Medicine, Huazhong Agricultural University, Rm 321 Vet. Teaching Hospital BLDG, No.1 Shizishan St., Hongshan District, Wuhan City, 430070, Hubei Province, China.
Chaohao WangCollege of Veterinary Medicine, Huazhong Agricultural University, Rm 321 Vet. Teaching Hospital BLDG, No.1 Shizishan St., Hongshan District, Wuhan City, 430070, Hubei Province, China.
Xiaoya LiuCollege of Veterinary Medicine, Huazhong Agricultural University, Rm 321 Vet. Teaching Hospital BLDG, No.1 Shizishan St., Hongshan District, Wuhan City, 430070, Hubei Province, China.
Hehao OuyangCollege of Veterinary Medicine, Huazhong Agricultural University, Rm 321 Vet. Teaching Hospital BLDG, No.1 Shizishan St., Hongshan District, Wuhan City, 430070, Hubei Province, China.
Wanfeng JiCollege of Veterinary Medicine, Huazhong Agricultural University, Rm 321 Vet. Teaching Hospital BLDG, No.1 Shizishan St., Hongshan District, Wuhan City, 430070, Hubei Province, China.
Jiahao LiuCollege of Veterinary Medicine, Huazhong Agricultural University, Rm 321 Vet. Teaching Hospital BLDG, No.1 Shizishan St., Hongshan District, Wuhan City, 430070, Hubei Province, China.
Xueyu LiaoCollege of Veterinary Medicine, Huazhong Agricultural University, Rm 321 Vet. Teaching Hospital BLDG, No.1 Shizishan St., Hongshan District, Wuhan City, 430070, Hubei Province, China.
Junyi LiCollege of Veterinary Medicine, Huazhong Agricultural University, Rm 321 Vet. Teaching Hospital BLDG, No.1 Shizishan St., Hongshan District, Wuhan City, 430070, Hubei Province, China.
Changmin HuCollege of Veterinary Medicine, Huazhong Agricultural University, Rm 321 Vet. Teaching Hospital BLDG, No.1 Shizishan St., Hongshan District, Wuhan City, 430070, Hubei Province, China. hcm@mail.hzau.edu.cn.
Huazhong Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feline infectious peritonitis (FIP) is a systemic, potentially fatal viral disease. The objectives of this study were to review clinical and laboratory features and treatment of cats highly suspected of FIP in Wuhan, China. The clinical records of 127 cats highly suspected of FIP were reviewed for history, clinical signs, physical findings, and diagnostic test results. Sex, neutering status, breed, age, and month of onset of disease were compared with the characteristics of the clinic population. Age and neutering status were significantly correlated with FIP-suspicion. Sex, breed and onset month were not associated with FIP. There were many more FIP-suspected cases in cats in young cats or male intact cats. Effusion was observed in 85.8% of the FIP-suspected cats. Increased serum amyloid A (SAA) and lymphopenia were common laboratory abnormalities in the FIP cases. Furthermore, 91.7% of the cats highly suspected of FIP had an albumin/globulin (A/G) ratio < 0.6, while 85.3% had an A/G ratio < 0.5. The mortality rate for FIP-suspected cats was 67%, and six submitted cases were confirmed by FIP-specific immunohistochemistry. Of the 30 cats treated with GS-441524 and/or GC376, 29 were clinically cured. The study highlights the diverse range of clinical manifestations by clinicians in diagnosing this potentially fatal disease. A/G ratio and SAA were of higher diagnostic value. GS-441524 and GC376 were efficient for the treatment of FIP-suspected cats.

Indexed as

AnimalsCatsChinaCoronavirus, FelineFeline Infectious PeritonitisFemaleGlobulinsMaleRetrospective StudiesSerum AlbuminSerum Amyloid A ProteinGlobulinsSerum AlbuminSerum Amyloid A Protein

Identifiers

PMID33664426
PMCPMC7970852
OpenAlexW3135709316

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.