ArticleScientific reports2021
Comparative transcriptome and metabolome profiling reveal molecular mechanisms underlying OsDRAP1-mediated salt tolerance in rice.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 58 citations in OpenAlex.
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- Genomic insights into the diversity of rice cultivars developed in Heilongjiang Province, China.Journal of Zhejiang University. Science. B · 2025Article
- Genomic and translational insights into eIF2B-mediated salt tolerance in sea rice HD961.BMC biology · 2025Article
- Innovative metabolic reprogramming in rice: unlocking drought resilience through microbial consortia interaction and sustainable agriculture.3 Biotech · 2025Review
- Transcriptome analysis reveals no obvious unintended effects in the spleen of CRISPR/Cas9-mediated CD163 and pAPN double-knockout pigs.Functional & integrative genomics · 2025Article
- Synergistic Response Mechanisms in Rice Seedlings Exposed to Brown Planthopper Infestation and High-Temperature Stress.Plants (Basel, Switzerland) · 2025Article
- Gene metabolite relationships revealed metabolic adaptations of rice salt tolerance.Scientific reports · 2025Article
- Integrated metabolomic and transcriptomic analysis reveals the role of root phenylpropanoid biosynthesis pathway in the salt tolerance of perennial ryegrass.BMC plant biology · 2024Article
- Understanding of Plant Salt Tolerance Mechanisms and Application to Molecular Breeding.International journal of molecular sciences · 2024Review
- Ambient temperature regulates root circumnutation in rice through the ethylene pathway: transcriptome analysis reveals key genes involved.Frontiers in plant science · 2024Article
- Responses of transcriptome and metabolome in peanut leaves to dibutyl phthalate during whole growth period.Frontiers in plant science · 2024Article
- Transcriptomic and metabolomic analyses reveal the differential accumulation of phenylpropanoids and terpenoids in hemp autotetraploid and its diploid progenitor.BMC plant biology · 2023Article
- Biocuration of a Transcription Factors Network Involved in Submergence Tolerance during Seed Germination and Coleoptile Elongation in Rice (Plants (Basel, Switzerland) · 2023Article
- New Genes Identified as Modulating Salt Tolerance in Maize Seedlings Using the Combination of Transcriptome Analysis and BSA.Plants (Basel, Switzerland) · 2023Article
- Changes in the Histology of Walnut (International journal of molecular sciences · 2023Article
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- Multi-omics Analysis of YoungPhenomics (Cham, Switzerland) · 2023Article
- Navigating rice seedling cold resilience: QTL mapping in two inbred line populations and the search for genes.Frontiers in plant science · 2023Article
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9 authors at 3 institutions in 1 country.
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Abstract
Integration of transcriptomics and metabolomics data can provide detailed information for better understanding the molecular mechanisms underlying salt tolerance in rice. In the present study, we report a comprehensive analysis of the transcriptome and metabolome of rice overexpressing the OsDRAP1 gene, which encodes an ERF transcription factor and was previously identified to be conferring drought tolerance. Phenotypic analysis showed that OsDRAP1 overexpression (OE) improved salt tolerance by increasing the survival rate under salt stress. OsDRAP1 affected the physiological indices such as superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) to enhance redox homeostasis and membrane stability in response to salt stress. Higher basal expression of OsDRAP1 resulted in differential expression of genes that potentially function in intrinsic salt tolerance. A core set of genes with distinct functions in transcriptional regulation, organelle gene expression and ion transport were substantially up-regulated in the OE line in response to salt stress, implying their important role in OsDRAP1-mediated salt tolerance. Correspondingly, metabolome profiling detected a number of differentially metabolites in the OE line relative to the wild type under salt stress. These metabolites, including amino acids (proline, valine), organic acids (glyceric acid, phosphoenolpyruvic acid and ascorbic acid) and many secondary metabolites, accumulated to higher levels in the OE line, demonstrating their role in salt tolerance. Integration of transcriptome and metabolome analysis highlights the crucial role of amino acids and carbohydrate metabolism pathways in OsDRAP1-mediated salt tolerance.
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