ArticleScientific reports2021
Differences in clinical severity of respiratory viral infections in hospitalized children.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Twenty-five years of human metapneumovirus research.Clinical microbiology reviews · 2026Review
- Viral Landscape, Clinical Impact, and Management Trends in Hospitalized Children for Viral-Associated Lower Respiratory Tract Diseases: A Comparative Analysis of Two Post-Pandemic Seasons in Rome, Italy.Journal of medical virology · 2026Observational
- Age- and Virus-Composition-Aware Interpretation of Respiratory Viral Co-Detection Using Same-Day C-Reactive Protein Profiles: A 2008-2024 Multiplex PCR Laboratory Cohort Study.Microorganisms · 2026Article
- Virus-Specific Impact of Respiratory Viruses on Adult Emergency Department Outcomes.Journal of medical virology · 2026Article
- Pathogen and Patient Characteristics and the Severity of Viral Respiratory Infections in Children.JAMA network open · 2026Article
- Molecular epidemiology of respiratory viral infections in hospitalized children in Novosibirsk, Russia, 2021-2023.Frontiers in pediatrics · 2026Article
- Epidemiology of severe acute respiratory infections in South Korea: a nationwide surveillance study.BMC pulmonary medicine · 2025Article
- Epidemiology and Genetic Diversity of Human Metapneumovirus in Patients with Severe Acute Respiratory Infection from 2023 to 2024 in Ningxia, China.Diseases (Basel, Switzerland) · 2025Article
- Evaluation of common respiratory viruses other than SARS-CoV-2 in hospitalized children during the COVID-19 pandemic.BMC infectious diseases · 2025Article
- Epidemiological study of post-pandemic pediatric common respiratory pathogens using multiplex detection.Virology journal · 2024Article
- Impact of SARS-CoV-2 Pandemic on Emergency Hospitalizations for Acute Respiratory Infections: The Experience of a Paediatric Tertiary Care Hospital in Italy.Influenza and other respiratory viruses · 2024Article
- Article
- Influenza versus other respiratory viruses - assessing severity among hospitalised children, Belgium, 2011 to 2020.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023Observational
- The burden of hospital-attended influenza in Norwegian children.Frontiers in pediatrics · 2022Article
- Potential Neurocognitive Symptoms Due to Respiratory Syncytial Virus Infection.Pathogens (Basel, Switzerland) · 2021Review
- Bacterial and Viral Coinfections with the Human Respiratory Syncytial Virus.Microorganisms · 2021Review
- Disappearance of Seasonal Respiratory Viruses in Children Under Two Years Old During COVID-19 Pandemic: A Monocentric Retrospective Study in Milan, Italy.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
Abstract
It is uncertain whether clinical severity of an infection varies by pathogen or by multiple infections. Using hospital-based surveillance in children, we investigate the range of clinical severity for patients singly, multiply, and not infected with a group of commonly circulating viruses in Nha Trang, Vietnam. RT-PCR was performed to detect 13 respiratory viruses in nasopharyngeal samples from enrolled patients. We apply a novel clinical severity score and examine associations with the odds of being severe and differences in raw severity scores. We find no difference in severity between 0-, 1-, and 2-concurrent infections and little differences in severity between specific viruses. We find RSV and HMPV infections to be associated with 2- and 1.5-fold increase in odds of being severe, respectively, and that infection with ADV is consistently associated with lower risk of severity. Clinically, based on the results here, if RSV or HMPV virus is suspected, PCR testing for confirmatory diagnosis and for detection of multiple coinfecting viruses would be fruitful to assess whether a patient's disease course is going to be severe.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.