ArticleTranslational psychiatry2021
Differential predictors for alcohol use in adolescents as a function of familial risk.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Alcohol Consumption Patterns: A Systematic Review of Demographic and Sociocultural Influencing Factors.International journal of environmental research and public health · 2022Pooled it
- The brain age gap as a predictor of alcohol initiation in adolescence.Developmental cognitive neuroscience · 2026Article
- The Brain Age Gap as a Predictor of Alcohol Initiation in Adolescence.bioRxiv : the preprint server for biology · 2026Article
- Classification of Adolescent Drinking via Behavioral, Biological, and Environmental Features: A Machine Learning Approach with Bias Control.medRxiv : the preprint server for health sciences · 2026Article
- Relations between impulsivity and drinking in adults with alcohol use disorder during recovery: A longitudinal observational cohort study.Alcohol, clinical & experimental research · 2026Observational
- Anxiety modulates odour-linked brain connectivity and alcohol dependence risk.Brain communications · 2026Article
- The link between early-life adversity and later alcohol use disorder: A role for microglia?Neurobiology of stress · 2025Article
- Regional and temporal dynamics of DNA methylation and epigenetic gene regulation in response to binge-like alcohol exposure in the adolescent mouse brain.Frontiers in molecular neuroscience · 2025Article
- Spectral Graph Sample Weighting for Interpretable Sub-cohort Analysis in Predictive Models for Neuroimaging.Predictive Intelligence in Medicine. PRIME (Workshop) · 2025Article
- Predictors of Alcohol Use, Alcohol-Related Problems, and Substance Use Following Adolescent Metabolic and Bariatric Surgery.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence.JAMA network open · 2024Article
- Drinking motives, personality traits and life stressors-identifying pathways to harmful alcohol use in adolescence using a panel network approach.Addiction (Abingdon, England) · 2023Article
- A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Alcohol, neuronal plasticity, and mitochondrial trafficking.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Alcohol and the Adolescent Brain: What We've Learned and Where the Data Are Taking Us.Alcohol research : current reviews · 2022Review
- Sex-specific associations between subcortical morphometry in childhood and adult alcohol consumption: A 17-year follow-up study.NeuroImage. Clinical · 2021Article
Corrections and comments
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Authors and funding
27 authors at 20 institutions in 7 countries.
Funding
Abstract
Traditional models of future alcohol use in adolescents have used variable-centered approaches, predicting alcohol use from a set of variables across entire samples or populations. Following the proposition that predictive factors may vary in adolescents as a function of family history, we used a two-pronged approach by first defining clusters of familial risk, followed by prediction analyses within each cluster. Thus, for the first time in adolescents, we tested whether adolescents with a family history of drug abuse exhibit a set of predictors different from adolescents without a family history. We apply this approach to a genetic risk score and individual differences in personality, cognition, behavior (risk-taking and discounting) substance use behavior at age 14, life events, and functional brain imaging, to predict scores on the alcohol use disorders identification test (AUDIT) at age 14 and 16 in a sample of adolescents (N = 1659 at baseline, N = 1327 at follow-up) from the IMAGEN cohort, a longitudinal community-based cohort of adolescents. In the absence of familial risk (n = 616), individual differences in baseline drinking, personality measures (extraversion, negative thinking), discounting behaviors, life events, and ventral striatal activation during reward anticipation were significantly associated with future AUDIT scores, while the overall model explained 22% of the variance in future AUDIT. In the presence of familial risk (n = 711), drinking behavior at age 14, personality measures (extraversion, impulsivity), behavioral risk-taking, and life events were significantly associated with future AUDIT scores, explaining 20.1% of the overall variance. Results suggest that individual differences in personality, cognition, life events, brain function, and drinking behavior contribute differentially to the prediction of future alcohol misuse. This approach may inform more individualized preventive interventions.
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