ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Glutamatergic Neurons in the Preoptic Hypothalamus Promote Wakefulness, Destabilize NREM Sleep, Suppress REM Sleep, and Regulate Cortical Dynamics.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- Article
- Mechanisms of Heat-Induced Sleep Disruption in Aging: A Narrative Review.Clocks & sleep · 2026Review
- The ventrolateral preoptic nucleus: a multisystem integrator in sleep-wake regulation.Frontiers in neuroscience · 2026Review
- The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Review
- Chemogenetic Modulation of PreopticInternational journal of molecular sciences · 2024Article
- Efferent pathways from the suprachiasmatic nucleus to the horizontal limbs of diagonal band promote NREM sleep during the dark phase in mice.BMC neuroscience · 2024Article
- Regulation of stress-induced sleep fragmentation by preoptic glutamatergic neurons.Current biology : CB · 2024Article
- Elevated peripheral glutamate and upregulated expression of NMDA receptor NR1 subunit in insomnia disorder.Frontiers in psychiatry · 2024Article
- Genes Associated with Altered Brain Structure and Function in Obstructive Sleep Apnea.Biomedicines · 2023Article
- Distinct roles of amylin and oxytocin signaling in intrafamilial social behaviors at the medial preoptic area of common marmosets.Communications biology · 2023Article
- Whole-brain monosynaptic inputs to lateral periaqueductal gray glutamatergic neurons in mice.CNS neuroscience & therapeutics · 2023Article
- Cross species review of the physiological role of D-serine in translationally relevant behaviors.Amino acids · 2023Review
- Calcium Dynamics of the Ventrolateral Preoptic GABAergic Neurons during Spontaneous Sleep-Waking and in Response to Homeostatic Sleep Demands.International journal of molecular sciences · 2023Article
- Article
- Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism.International journal of molecular sciences · 2023Review
- Lateral Preoptic Hypothalamus: A Window to Understanding Insomnia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neuro-orchestration of sleep and wakefulness.Nature neuroscience · 2023Review
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Clinical and experimental data from the last nine decades indicate that the preoptic area of the hypothalamus is a critical node in a brain network that controls sleep onset and homeostasis. By contrast, we recently reported that a group of glutamatergic neurons in the lateral and medial preoptic area increases wakefulness, challenging the long-standing notion in sleep neurobiology that the preoptic area is exclusively somnogenic. However, the precise role of these subcortical neurons in the control of behavioral state transitions and cortical dynamics remains unknown. Therefore, in this study, we used conditional expression of excitatory hM3Dq receptors in these preoptic glutamatergic (Vglut2
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.