Evidence map›Paper›PMID 33664107›Full record

Observational studyAJNR. American journal of neuroradiology2021

A Diagnostic Algorithm for Posterior Fossa Tumors in Children: A Validation Study.

C A P F Alves, U Löbel, J S Martin-Saavedra, S Toescu, M H Tsunemi, S R Teixeira, K Mankad, D Hargrave, T S Jacques, C da Costa Leite and 3 more

Abstract readObservational StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. [Pediatric posterior fossa tumors].Radiologie (Heidelberg, Germany) · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

C A P F AlvesFrom the Division of Neuroradiology (C.A.P.F.A., J.S.M.-S. S.R.T., F.G.G., A.V.), Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania alvesc@email.chop.edu.ORCID 0000-0001-5877-9086
U LöbelRadiology Department (U.L., K.M., F.D.), UCL Great Ormond Street Hospital for Children, London, UK.ORCID 0000-0001-9844-3464
J S Martin-SaavedraFrom the Division of Neuroradiology (C.A.P.F.A., J.S.M.-S. S.R.T., F.G.G., A.V.), Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0002-4197-5424
S ToescuDepartment of Neurosurgery (S.T.), UCL Great Ormond Street Hospital for Children, London, UK.ORCID 0000-0001-8768-9231
M H TsunemiDepartment of Biostatistics (M.H.T.), Instituto de Biociências, São Paulo State University, São Paul, Brazil.ORCID 0000-0002-9585-4230
S R TeixeiraFrom the Division of Neuroradiology (C.A.P.F.A., J.S.M.-S. S.R.T., F.G.G., A.V.), Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0001-5845-058X
K MankadRadiology Department (U.L., K.M., F.D.), UCL Great Ormond Street Hospital for Children, London, UK.ORCID 0000-0001-5979-9337
D HargravePediatric Oncology Unit (D.H.), UCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0001-8219-9807
T S JacquesDevelopmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0002-7833-2158
C da Costa LeiteDepartment of Radiology (C.d.C.L.), Hospital das Clinicas, Faculdade de Medicina de Sao Paulo, Sao Paulo.ORCID 0000-0002-1168-0780
F G GonçalvesFrom the Division of Neuroradiology (C.A.P.F.A., J.S.M.-S. S.R.T., F.G.G., A.V.), Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0002-8889-9879
A VossoughFrom the Division of Neuroradiology (C.A.P.F.A., J.S.M.-S. S.R.T., F.G.G., A.V.), Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0003-1346-427X
F D'ArcoRadiology Department (U.L., K.M., F.D.), UCL Great Ormond Street Hospital for Children, London, UK.ORCID 0000-0001-7396-591X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposePrimary posterior fossa tumors comprise a large group of neoplasias with variable aggressiveness and short and long-term outcomes. This study aimed to validate the clinical usefulness of a radiologic decision flow chart based on previously published neuroradiologic knowledge for the diagnosis of posterior fossa tumors in children. MATERIALS AND

methodsA retrospective study was conducted (from January 2013 to October 2019) at 2 pediatric referral centers, Children's Hospital of Philadelphia, United States, and Great Ormond Street Hospital, United Kingdom. Inclusion criteria were younger than 18 years of age and histologically and molecularly confirmed posterior fossa tumors. Subjects with no available preoperative MR imaging and tumors located primarily in the brain stem were excluded. Imaging characteristics of the tumors were evaluated following a predesigned, step-by-step flow chart. Agreement between readers was tested with the Cohen κ, and each diagnosis was analyzed for accuracy.

resultsA total of 148 cases were included, with a median age of 3.4 years (interquartile range, 2.1-6.1 years), and a male/female ratio of 1.24. The predesigned flow chart facilitated identification of pilocytic astrocytoma, ependymoma, and medulloblastoma

conclusionsThe modified flow chart offers a structured tool to aid in the adjunct diagnosis of pediatric posterior fossa tumors. Our results also establish a useful starting point for prospective clinical studies and for the development of automated algorithms, which may provide precise and adequate diagnostic tools for these tumors in clinical practice.

Indexed as

AlgorithmsAdolescentChildChild, PreschoolFemaleHumansInfantInfratentorial NeoplasmsMagnetic Resonance ImagingMale

Identifiers

PMID33664107
PMCPMC8115380

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.