Evidence map›Paper›PMID 33664106›Full record

Observational studyAJNR. American journal of neuroradiology2021

Posterior Circulation Endovascular Thrombectomy for Large-Vessel Occlusion: Predictors of Favorable Clinical Outcome and Analysis of First-Pass Effect.

A M Alexandre, I Valente, A Consoli, M Piano, L Renieri, J D Gabrieli, R Russo, A A Caragliano, M Ruggiero, A Saletti and 10 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05708079 (Multidimensional Evaluation of Patients With Acute Ischemic Stroke Undergoing Pharmacological and Endovascular Revascularization Procedures for the Identification of Positive Prognostic Factors), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05708079 unknown statusnot on this map

Multidimensional Evaluation of Patients With Acute Ischemic Stroke Undergoing Pharmacological and Endovascular Revascularization Procedures for the Identification of Positive Prognostic Factors

Typeobservational_patient_registrySponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2020 to 2023Enrolled600ConditionsStroke, Endovascular Thrombectomy, Ischemic StrokeArmsEndovascular thrombectomy
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
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  8. Predictors and outcomes of first pass efficacy in posterior circulation strokes: Insights from STAR collaboration.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  9. Effect of MR-guided perfusion imaging mismatch profiles within 6 h on endovascular thrombectomy outcomes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  10. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 11 institutions in 5 countries.

A M AlexandreFrom the Unità Operativa Complessa Radiologia e Neuroradiologia (A.M.A., I.V., A.P.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia. Fondazione Policlinico Universitario A. Gemelli Istituto Di Ricovero e Cura a Carattere Scientifico, Roma, Italia andrea.alexandre@policlinicogemelli.it.ORCID 0000-0002-8080-3916
I ValenteFrom the Unità Operativa Complessa Radiologia e Neuroradiologia (A.M.A., I.V., A.P.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia. Fondazione Policlinico Universitario A. Gemelli Istituto Di Ricovero e Cura a Carattere Scientifico, Roma, Italia.ORCID 0000-0002-0451-2105
A ConsoliDiagnostic and Interventional Neuroradiology (A.Consoli, R.R.), Foch Hospital, Suresnes, France.ORCID 0000-0001-6640-8541
M PianoNeuroradiologia (M.Piano, A.Cervo), Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Italy.ORCID 0000-0003-0470-1202
L RenieriUOC Interventistica Neurovascolare (L.R., N.L.), Azienda Ospedaliera Universitaria Careggi, Firenze, Italy.ORCID 0000-0001-8966-8266
J D GabrieliNeuroradiology Unit (J.D.G.), Policlinico Universitario di Padova, Padua, Italy.ORCID 0000-0001-6905-3627
R RussoDiagnostic and Interventional Neuroradiology (A.Consoli, R.R.), Foch Hospital, Suresnes, France.ORCID 0000-0002-9091-7394
A A CaraglianoNeuroradiology Unit, Biomedical Sciences and Morphologic and Functional Images (A.A.C., S.L.V.), Azienda Ospedaliera Universitaria Policlinico G. Martino, Messina, Italy.ORCID 0000-0003-3493-0145
M RuggieroNeuroradiology Unit (M.R., C.C.), Azienda Unità Sanitaria Locale Romagna, Cesena, Italy.ORCID 0000-0002-3612-4289
A SalettiInterventional Neuroradiology (A.S.), S. Anna University Hospital of Ferrara, Ferrara, Italy.ORCID 0000-0001-6984-113X
G A LazzarottiDepartment of Neuroradiology (G.A.L., M.C.), Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.ORCID 0000-0002-7135-758X
M PileggiDepartment of Neuroradiology (M.Pileggi), Neurocenter of Southern Switzerland, Lugano, Switzerland.ORCID 0000-0002-7691-8999
N LimbucciUOC Interventistica Neurovascolare (L.R., N.L.), Azienda Ospedaliera Universitaria Careggi, Firenze, Italy.ORCID 0000-0002-0432-5414
M CosottiniDepartment of Neuroradiology (G.A.L., M.C.), Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.ORCID 0000-0001-9400-6574
A CervoNeuroradiologia (M.Piano, A.Cervo), Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Italy.ORCID 0000-0002-5839-9929
F ViaroUOC Neurologia (F.V.), Policlinico Universitario di Padova, Padua, Italy.ORCID 0000-0002-5750-8345
S L VinciNeuroradiology Unit, Biomedical Sciences and Morphologic and Functional Images (A.A.C., S.L.V.), Azienda Ospedaliera Universitaria Policlinico G. Martino, Messina, Italy.ORCID 0000-0002-7443-8270
C CommodaroNeuroradiology Unit (M.R., C.C.), Azienda Unità Sanitaria Locale Romagna, Cesena, Italy.ORCID 0000-0002-9649-9824
F PilatoUOC Neurologia (F.P.), Fondazione Policlinico Universitario A. Gemelli, Istituto Di Ricovero e Cura a Carattere Scientifico, Roma, Italy.ORCID 0000-0002-7248-3916
A PedicelliFrom the Unità Operativa Complessa Radiologia e Neuroradiologia (A.M.A., I.V., A.P.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia. Fondazione Policlinico Universitario A. Gemelli Istituto Di Ricovero e Cura a Carattere Scientifico, Roma, Italia.ORCID 0000-0002-2558-8838
Advanced Radiation Therapy (United States) · USAgostino Gemelli University Polyclinic · ITAzienda Ospedaliera Universitaria Pisana · ITAzienda Ospedaliera Universitaria Policlinico "G. Martino" · ITAzienda Ospedaliero-Universitaria Careggi · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITAzienda Unità Sanitaria Locale Della Romagna · ITHôpital Foch · FRUniversity of Padua · ITLaboratory for Biomedical Neurosciences · CHUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeSuccessful vessel recanalization in posterior circulation large-vessel occlusion is considered crucial, though the evidence of clinical usefulness, compared with the anterior circulation, is not still determined. The aim of this study was to evaluate predictors of favorable clinical outcome and to analyze the effect of first-pass thrombectomy. MATERIALS AND

methodsA retrospective, multicenter, observational study was conducted in 10 high-volume stroke centers in Europe, including the period from January 2016 to July 2019. Only patients with an acute basilar artery occlusion or a single, dominant vertebral artery occlusion ("functional" basilar artery occlusion) who had a 3-month mRS were included. Clinical, procedural, and radiologic data were evaluated, and the association between these parameters and both the functional outcome and the first-pass effect was assessed.

resultsA total of 191 patients were included. A lower baseline NIHSS score (adjusted OR, 0.77; 95% CI, 0.61-0.96;

conclusionsThe analysis of our retrospective series demonstrates that a lower baseline NIHSS score and a higher MR imaging posterior circulation ASPECTS were predictors of good clinical outcome. The use of large-bore catheters was a positive predictor of first-pass modified TICI 2b/3; the use of a combined technique was a negative predictor.

Indexed as

AgedAged, 80 and overArterial Occlusive DiseasesBasilar ArteryCathetersEndovascular ProceduresEuropeFemaleHumansMaleMiddle AgedReperfusionRetrospective StudiesStrokeThrombectomyTreatment Outcome

Identifiers

PMID33664106
PMCPMC8115369
OpenAlexW3133696516

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.