Evidence map›Paper›PMID 33664060›Full record

ArticleScience immunology2021

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8

Benedikt Agerer, Maximilian Koblischke, Venugopal Gudipati, Luis Fernando Montaño-Gutierrez, Mark Smyth, Alexandra Popa, Jakob-Wendelin Genger, Lukas Endler, David M Florian, Vanessa Mühlgrabner and 33 more

Abstract read
In one paragraph

Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Review
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  8. Review
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  10. Review
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  12. Article
  13. Characterization of human CMV-specific CD8Cell reports methods · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Impaired and restored CD8Frontiers in immunology · 2025
    Article
  20. Article

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Benedikt AgererCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID 0000-0002-0044-8396
Maximilian KoblischkeCenter for Virology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-1223-4990
Venugopal GudipatiInstitute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-6647-0708
Luis Fernando Montaño-GutierrezSt. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.ORCID 0000-0003-2383-1483
Mark SmythCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID 0000-0003-2592-1722
Alexandra PopaCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID 0000-0001-7156-272X
Jakob-Wendelin GengerCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID 0000-0003-4502-1094
Lukas EndlerCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID 0000-0002-9115-8756
David M FlorianCenter for Virology, Medical University of Vienna, Vienna, Austria.
Vanessa MühlgrabnerInstitute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Marianne GraningerCenter for Virology, Medical University of Vienna, Vienna, Austria.
Stephan W AberleCenter for Virology, Medical University of Vienna, Vienna, Austria.
Anna-Maria HusaSt. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.ORCID 0000-0002-3105-6694
Lisa Ellen ShawDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-2273-7655
Alexander LercherCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID 0000-0003-3478-5304
Pia GattingerDepartment of Pathophysiology and Allergy Research, Division of Immunopathology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-6724-8543
Ricard Torralba-GombauCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID 0000-0002-9498-6717
Doris TrapinInstitute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Thomas PenzCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Daniele BarrecaCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID 0000-0003-3373-9939
Ingrid FaeDepartment of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-7698-5526
Sabine WendaDepartment of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-0387-6601
Marianna TraugottDepartment of Medicine 4, Clinic Favoriten, Vienna, Austria.ORCID 0000-0003-0534-1966
Gernot WalderDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Winfried F PicklInstitute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Volker ThielInstitute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
Franz AllerbergerAustrian Agency for Health and Food Safety (AGES), Vienna, Austria.ORCID 0000-0002-0045-8164
Hannes StockingerInstitute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-6404-4430
Elisabeth Puchhammer-StöcklCenter for Virology, Medical University of Vienna, Vienna, Austria.
Wolfgang WeningerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Gottfried FischerInstitute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-3442-3680
Wolfgang HoeplerDepartment of Medicine 4, Clinic Favoriten, Vienna, Austria.ORCID 0000-0003-2653-3844
Erich PawelkaDepartment of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-0199-0539
Alexander ZoufalyDepartment of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
Rudolf ValentaInstitute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Christoph BockCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID 0000-0001-6091-3088
Wolfgang PasterSt. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.ORCID 0000-0002-5537-2886
René GeyereggerSt. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.ORCID 0000-0002-5762-790X
Matthias FarlikDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-0698-2992
Florian HalbritterSt. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.ORCID 0000-0003-2452-4784
Johannes B HuppaInstitute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-2634-8198
Judith H AberleCenter for Virology, Medical University of Vienna, Vienna, Austria.
Andreas BergthalerCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. abergthaler@cemm.oeaw.ac.at.ORCID 0000-0003-0597-1976

Funding

European Research Council 679146
6 · The paper itself

Abstract

CD8

Indexed as

COVID-19Epitopes, T-LymphocyteImmunity, CellularMutationSARS-CoV-2CD8-Positive T-LymphocytesCell ProliferationHigh-Throughput Nucleotide SequencingHLA-A AntigensHumansInterferon-gammaPeptidesEpitopes, T-LymphocyteHLA-A AntigensIFNG protein, humanInterferon-gammaPeptides

Identifiers

PMID33664060
PMCPMC8224398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.