Evidence map›Paper›PMID 33663814›Full record

ReviewTrends in neurosciences2021

Understanding Vulnerability and Adaptation in Early Brain Development using Network Neuroscience.

Alice M Graham, Mollie Marr, Claudia Buss, Elinor L Sullivan, Damien A Fair

Open access · greenAbstract readReview
In one paragraph

Review in Trends in neurosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. High-resolution in utero SV2A PET imaging of the nonhuman primate brain using the NeuroEXPLORER.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. From Genetics to Function: the Role of ABCA12 in Autism Neurobiology.Journal of molecular neuroscience : MN · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Towards personalized precision functional mapping in infancy.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  16. Linking fast and slow: The case for generative models.Network neuroscience (Cambridge, Mass.) · 2024
    Review
  17. Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Alice M GrahamDepartment of Psychiatry, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.
Mollie MarrDepartment of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.
Claudia BussDepartment of Medical Psychology, Charité University of Medicine Berlin, Luisenstrasse 57, 10117 Berlin, Germany; Development, Health, and Disease Research Program, University of California, Irvine, 837 Health Sciences Drive, Irvine, California, 92697, USA.
Elinor L SullivanDepartment of Psychiatry, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA; Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA; Division of Neuroscience, Oregon National Primate Research Center, 505 NW 185th Ave., Beaverton, OR, 97006, USA.
Damien A FairThe Masonic Institute of the Developing Brain, The University of Minnesota, Department of Pediatrics, The University of Minnesota Institute of Child Development, The University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: faird@umn.edu.
Oregon Health & Science University · USCharité - Universitätsmedizin Berlin · DEUniversity of Minnesota · US

Funding

Supplement to Prevention Research Center: Parenting Among Women Who Are Opioid Users, Project 2P50DA048756 · NIDA · UNIVERSITY OF OREGON · PI MACKIEWICZ SEGHETE, KRISTEN L · 2019 to 2023
$18.0M
Identification of outcome-based sub-populations using deep phenotyping and precision functional mapping across ADHD and ASDR01MH096773 · NIMH · UNIVERSITY OF MINNESOTA · PI DOSENBACH, NICO, FAIR, DAMIEN A · 2012 to 2024
$9.4M
Oregon Clinical and Translational Research Institute TL1 ProgramTL1TR002371 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALLISON Deborah FRYER, JESSINA C MCGREGOR · 2017 to 2026
$6.2M
Developmental origins and early detection of ADHD and dysregulatory psychopathologyR01MH124824 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI SULLIVAN, ELINOR L. · 2021 to 2025
$3.8M
Brain trajectories in ADHDR01MH115357 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI FAIR, DAMIEN A, NIGG, JOEL T · 2017 to 2021
$3.8M
The Impact of Maternal Obesity and Poor Antenatal Nutrition on Offspring RDoC Dimensions and Risk for Neurodevelopmental DisordersR01MH117177 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T, SULLIVAN, ELINOR L. · 2018 to 2022
$3.6M
Intergenerational Effects of Maternal Childhood Trauma on the Fetal BrainR01MH105538 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, FAIR, DAMIEN A · 2015 to 2019
$3.5M
2/7: Longitudinal evaluation of the impact of the COVID-19 pandemic on high-risk new and expectant mothersR34DA050291 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI FAIR, DAMIEN A, GRAHAM, ALICE M · 2019 to 2021
$977k
LINKS BETWEEN MATERNAL PSYCHOLOGICAL STRESS AND INFLAMMATION DURING PREGNANCY AND POTENTIAL FOR PREVENTIVE INTERVENTION: Supplement to R00MH111805R00MH111805 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI GRAHAM, ALICE M · 2018 to 2020
$934k
Maternal psychological stress during pregnancy as a key mechanism for the intergenerational transmission of childhood traumatic stressF30MH118762 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI MARR, MOLLIE CHRISTINE · 2018 to 2022
$246k
NCATS NIH HHS TL1 TR002371NIDA NIH HHS P50 DA048756NIDA NIH HHS R34 DA050291NIMH NIH HHS F30 MH118762NIMH NIH HHS R00 MH111805NIMH NIH HHS R01 MH096773NIMH NIH HHS R01 MH105538NIMH NIH HHS R01 MH115357NIMH NIH HHS R01 MH117177NIMH NIH HHS R01 MH124824
6 · The paper itself

Abstract

Early adversity influences brain development and emerging behavioral phenotypes relevant for psychiatric disorders. Understanding the effects of adversity before and after conception on brain development has implications for contextualizing current public health crises and pervasive health inequities. The use of functional magnetic resonance imaging (fMRI) to study the brain at rest has shifted understanding of brain functioning and organization in the earliest periods of life. Here we review applications of this technique to examine effects of early life stress (ELS) on neurodevelopment in infancy, and highlight targets for future research. Building on the foundation of existing work in this area will require tackling significant challenges, including greater inclusion of often marginalized segments of society, and conducting larger, properly powered studies.

Indexed as

NeurosciencesStress, PsychologicalBrainBrain MappingHumansMagnetic Resonance ImagingNeural Pathwaysbrain developmentearly life stressfunctional brain networksprenatal stressresting state functional connectivity MRI

Identifiers

PMID33663814
PMCPMC8216738
OpenAlexW3133773908

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.