Evidence map›Paper›PMID 33663647›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2021

Economic evaluation of whole genome sequencing for pathogen identification and surveillance - results of case studies in Europe and the Americas 2016 to 2019.

Frank Alleweldt, Şenda Kara, Kris Best, Frank M Aarestrup, Martin Beer, Theo M Bestebroer, Josefina Campos, Gabriele Casadei, Isabel Chinen, Gary Van Domselaar and 17 more

Abstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The impact of integrated genomic surveillance on non-typhoidalThe Lancet regional health. Western Pacific · 2025
    Article
  8. Outbreak investigations ofEpidemiology and infection · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Whole-genome sequencing for surveillance of antimicrobial resistance in Ecuador: present and future implications.Revista panamericana de salud publica = Pan American journal of public health · 2023
    Article
  16. Estimated Reduction in the Burden of NontyphoidalFoodborne pathogens and disease · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Frank AlleweldtCivic Consulting, Berlin, Germany.
Şenda KaraCivic Consulting, Berlin, Germany.
Kris BestCivic Consulting, Berlin, Germany.
Frank M AarestrupNational Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark.
Martin BeerFriedrich-Loeffler-Institut, Greifswald, Germany.
Theo M BestebroerErasmus University Medical Center, Rotterdam, The Netherlands.
Josefina CamposINEI-ANLIS Dr Carlos G Malbrán, Buenos Aires, Argentina.
Gabriele CasadeiIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Parma, Italy.
Isabel ChinenINEI-ANLIS Dr Carlos G Malbrán, Buenos Aires, Argentina.
Gary Van DomselaarPublic Health Agency of Canada, Winnipeg, Canada.
Catherine DominguezMaryland Department of Health, Baltimore, United States.
Helen E EverettAnimal and Plant Health Agency, Addlestone, United Kingdom.
Ron Am FouchierErasmus University Medical Center, Rotterdam, The Netherlands.
Kathie GrantPublic Health England, London, United Kingdom.
Jonathan GreenPublic Health England, London, United Kingdom.
Dirk HöperFriedrich-Loeffler-Institut, Greifswald, Germany.
Jonathan JohnstonMaryland Department of Health, Baltimore, United States.
Marion Pg KoopmansErasmus University Medical Center, Rotterdam, The Netherlands.
Bas B Oude MunninkErasmus University Medical Center, Rotterdam, The Netherlands.
Robert MyersMaryland Department of Health, Baltimore, United States.
Celine NadonPublic Health Agency of Canada, Winnipeg, Canada.
Ami PatelMaryland Department of Health, Baltimore, United States.
Anne PohlmannFriedrich-Loeffler-Institut, Greifswald, Germany.
Stefano PongoliniIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Parma, Italy.
Aleisha ReimerPublic Health Agency of Canada, Winnipeg, Canada.
Shane ThiessenPublic Health Agency of Canada, Winnipeg, Canada.
Claudia WylezichFriedrich-Loeffler-Institut, Greifswald, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundWhole genome sequencing (WGS) is increasingly used for pathogen identification and surveillance.AimWe evaluated costs and benefits of routine WGS through case studies at eight reference laboratories in Europe and the Americas which conduct pathogen surveillance for avian influenza (two laboratories), human influenza (one laboratory) and food-borne pathogens (five laboratories).MethodsThe evaluation focused on the institutional perspective, i.e. the 'investment case' for implementing WGS compared with conventional methods, based on costs and benefits during a defined reference period, mostly covering at least part of 2017. A break-even analysis estimated the number of cases of illness (for the example of

Indexed as

Salmonella Food PoisoningAmericasAnimalsCost-Benefit AnalysisEuropeGenome, BacterialHumansWhole Genome SequencingCosts and benefits of pathogen surveillance using WGSEconomic evaluationNext Generation Sequencingsurveillance systemsWhole Genome Sequencing

Identifiers

PMID33663647
PMCPMC7934224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.