ArticleArthritis research & therapy2021
The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: diet has a weak causal effect.
Article in Arthritis research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Effects of Causal Beliefs About Gout on Public Views About Gout Management: A Randomized Experimental Study.Arthritis care & research · 2026Trial
- Uric Acid and Chronic Kidney Disease.Kidney medicine · 2026Review
- Serum uric acid and its metabolism-a vital factor in the inflammatory transformation of cancer.Journal of advanced research · 2026Review
- Airborne particulate matter enhances with monosodium urate crystals the secretion of IL-1β by human immune cells.medRxiv : the preprint server for health sciences · 2026Article
- Perceptions About Asymptomatic Hyperuricemia and Views About Urate-Lowering Therapy in People With Asymptomatic Hyperuricemia.Arthritis care & research · 2026Article
- Gouty inflammation: genetic mechanisms towards flare therapy.Current opinion in rheumatology · 2025Review
- Article
- Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment.Acta pharmacologica Sinica · 2025Review
- The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study.BMC public health · 2025Observational
- Association between gout, hyperuricaemia and Parkinson's disease risk: a cohort study in western Sweden (2001-2017).Rheumatology advances in practice · 2025Article
- The pathogenesis of gout.Journal of rheumatic diseases · 2025Review
- Changes in alcohol intake and serum urate changes: longitudinal analyses of annual medical examination database.Annals of the rheumatic diseases · 2024Article
- The Evolving Landscape of Gout in the Female: A Narrative Review.Gout, urate, and crystal deposition disease · 2023Article
- New animal model of chronic gout reproduces pathological features of the disease in humans.RMD open · 2023Article
- Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases.Biomolecules · 2023Review
- Interactions Between Genetic Risk and Diet Influencing Risk of Incident Female Gout: Discovery and Replication Analysis of Four Prospective Cohorts.Arthritis & rheumatology (Hoboken, N.J.) · 2023Article
- Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES.BMC public health · 2022Article
- Impact of adiposity on risk of female gout among those genetically predisposed: sex-specific prospective cohort study findings over >32 years.Annals of the rheumatic diseases · 2022Article
- Prevalence of hyperuricemia and the population attributable fraction of modifiable risk factors: Evidence from a general population cohort in China.Frontiers in public health · 2022Article
- Role of diet in hyperuricemia and gout.Best practice & research. Clinical rheumatology · 2021Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPrevention of hyperuricaemia (HU) is critical to the prevention of gout. Understanding causal relationships and relative contributions of various risk factors to hyperuricemia is therefore important in the prevention of gout. Here, we use attributable fraction to compare the relative contribution of genetic, dietary, urate-lowering therapy (ULT) and other exposures to HU. We use Mendelian randomisation to test for the causality of diet in urate levels.
methodsFour European-ancestry sample sets, three from the general population (n = 419,060) and one of people with gout (n = 6781) were derived from the Database of Genotypes and Phenotypes (ARIC, FHS, CARDIA, CHS) and UK Biobank. Dichotomised exposures to diet, genetic risk variants, BMI, alcohol, diuretic treatment, sex and age were used to calculate adjusted population and average attributable fractions (PAF/AAF) for HU (≥0.42 mmol/L [≥7 mg/dL]). Exposure to ULT was also assessed in the gout cohort. Two sample Mendelian randomisation was done in the UK Biobank using dietary pattern-associated genetic variants as exposure and serum urate levels as outcome.
resultsAdherence to dietary recommendations, BMI (< 25 kg/m
conclusionsDiet has a relatively minor role in determining serum urate levels and HU. In gout, the use of ULT was the largest attributable fraction tested for HU.
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