Evidence map›Paper›PMID 33663555›Full record

ArticleReproductive health2021

Comparative analysis of perinatal outcomes and birth defects amongst adolescent and older Ugandan mothers: evidence from a hospital-based surveillance database.

Robert Serunjogi, Linda Barlow-Mosha, Daniel Mumpe-Mwanja, Dhelia Williamson, Diana Valencia, Sarah C Tinker, Michelle R Adler, Joyce Namale-Matovu, Dennis Kalibbala, Jolly Nankunda and 4 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Robert SerunjogiMakerere University-Johns Hopkins University Research Collaboration, P. O. Box 23491, Kampala, Uganda. rserunjogi@mujhu.org.ORCID http://orcid.org/0000-0002-8694-1359
Linda Barlow-MoshaMakerere University-Johns Hopkins University Research Collaboration, P. O. Box 23491, Kampala, Uganda.
Daniel Mumpe-MwanjaMakerere University-Johns Hopkins University Research Collaboration, P. O. Box 23491, Kampala, Uganda.
Dhelia WilliamsonUS Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
Diana ValenciaUS Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
Sarah C TinkerUS Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
Michelle R AdlerUS Centers for Disease Control and Prevention (CDC), Kampala, Uganda.
Joyce Namale-MatovuMakerere University-Johns Hopkins University Research Collaboration, P. O. Box 23491, Kampala, Uganda.
Dennis KalibbalaMakerere University-Johns Hopkins University Research Collaboration, P. O. Box 23491, Kampala, Uganda.
Jolly NankundaDepartment of Paediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda.
Evelyn NabunyaDepartment of Obstetrics and Gynaecology, College of Health Sciences, Makerere University Kampala, Kampala, Uganda.
Doreen Birabwa-MaleDepartment of Obstetrics and Gynaecology, College of Health Sciences, Makerere University Kampala, Kampala, Uganda.
Josaphat ByamugishaDepartment of Obstetrics and Gynaecology, College of Health Sciences, Makerere University Kampala, Kampala, Uganda.
Philippa MusokeMakerere University-Johns Hopkins University Research Collaboration, P. O. Box 23491, Kampala, Uganda.
MUJHU Research Collaboration · UGMakerere University · UGCenters for Disease Control and Prevention · USCenters for Disease Control and Prevention · UG

Funding

CGH CDC HHS U01 GH000487CGH CDC HHS U01 GH002171U.S. President's Emergency Plan for AIDS Relief 1U10GH000487U.S. President's Emergency Plan for AIDS Relief 5U01GH000487U.S. President's Emergency Plan for AIDS Relief 5U01GH002171
6 · The paper itself

Abstract

backgroundUganda has one of the highest adolescent pregnancy rates in sub-Saharan Africa. We compared the risk of adverse birth outcomes between adolescents (age 12-19 years) and mothers (age 20-34 years) in four urban hospitals.

methodsMaternal demographics, HIV status, and birth outcomes of all live births, stillbirths, and spontaneous abortions delivered from August 2015 to December 2018 were extracted from a hospital-based birth defects surveillance database. Differences in the distributions of maternal and infant characteristics by maternal age groups were tested with Pearson's chi-square. Adjusted odds ratios (aORs) and 95% confidence intervals (CI) were calculated using logistic regression to compare the prevalence of adverse birth outcomes among adolescents to mothers 20-34 years.

resultsA total of 100,189 births were analyzed, with 11.1% among adolescent mothers and 89.0% among older mothers. Adolescent mothers had an increased risk of preterm delivery (aOR: 1.14; CI 1.06-1.23), low birth weight (aOR: 1.46; CI 1.34-1.59), and early neonatal deaths (aOR: 1.58; CI 1.23-2.02). Newborns of adolescent mothers had an increased risk of major external birth defects (aOR: 1.33; CI 1.02-1.76), specifically, gastroschisis (aOR: 3.20; CI 1.12-9.13) compared to mothers 20-34 years. The difference between the prevalence of gastroschisis among adolescent mothers (7.3 per 10,000 births; 95% CI 3.7-14.3) was statistically significant when compared to mothers 20-34 years (1.6 per 10,000 births; 95% CI 0.9-2.6).

conclusionsThis study found that adolescent mothers had an increased risk for several adverse birth outcomes compared to mothers 20-34 years, similar to findings in the region and globally. Interventions are needed to improve birth outcomes in this vulnerable population.

Indexed as

Perinatal DeathAdolescentAdultAge FactorsCesarean SectionChildCongenital AbnormalitiesFemaleGastroschisisHospitalsHumansInfantInfant, Low Birth WeightInfant, NewbornInfant, PrematureMaternal AgeAdolescentBirth defectsBirth outcomesEarly neonatal deathGastroschisisHospital-based surveillanceLow birth weightPretermSub-Saharan AfricaUganda

Identifiers

PMID33663555
PMCPMC7934544
OpenAlexW3135544514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.