Evidence map›Paper›PMID 33663530›Full record

ReviewCancer cell international2021

Challenges of applying multicellular tumor spheroids in preclinical phase.

Se Jik Han, Sangwoo Kwon, Kyung Sook Kim

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer cell international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 224 papers.

0numbers the graph read from it
0cells of the map it votes in
224citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

224 citing papers in PubMed.

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164 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Se Jik Han *Department of Biomedical Engineering, Graduate School, Kyung Hee University, Seoul, 02447, Korea.
Sangwoo Kwon *Department of Biomedical Engineering, College of Medicine, Kyung Hee University, Seoul, 02447, Korea.
Kyung Sook KimDepartment of Biomedical Engineering, College of Medicine, Kyung Hee University, Seoul, 02447, Korea. moosou94@khu.ac.kr.ORCID http://orcid.org/0000-0003-3572-1169

Funding

National Assembly (KR) 2020R1F1A1057505National Research Foundation of Korea 2020R1F1A1057505
6 · The paper itself

Abstract

The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is becoming an essential tool in cancer research as it expresses an intermediate complexity between 2D monolayer models and in vivo solid tumors. MCTs closely resemble in vivo solid tumors in many aspects, such as the heterogeneous architecture, internal gradients of signaling factors, nutrients, and oxygenation. MCTs have growth kinetics similar to those of in vivo tumors, and the cells in spheroid mimic the physical interaction of the tumors, such as cell-to-cell and cell-to-extracellular matrix interactions. These similarities provide great potential for studying the biological properties of tumors and a promising platform for drug screening and therapeutic efficacy evaluation. However, MCTs are not well adopted as preclinical tools for studying tumor behavior and therapeutic efficacy up to now. In this review, we addressed the challenges with MCTs application and discussed various efforts to overcome the challenges.

Indexed as

Drug screeningHigh-throughputMicrofluidicsMulticellular tumor spheroidsTherapeutic efficacy

Identifiers

PMID33663530
PMCPMC7934264

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.