Evidence map›Paper›PMID 33663494›Full record

ArticleBMC veterinary research2021

Hepatocyte ploidy in cats with and without hepatocellular carcinoma.

Jacqueline Post, Ingeborg M Langohr, Cynthia R L Webster, Peter Mottram, Chin-Chi Liu, Andrea Johnston

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jacqueline PostVeterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, LA, Baton Rouge, USA.
Ingeborg M LangohrPathobiological Sciences, School of Veterinary Medicine, Louisiana State University, LA, Baton Rouge, USA.
Cynthia R L WebsterVeterinary Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, MA, North Grafton, USA.
Peter MottramPathobiological Sciences, School of Veterinary Medicine, Louisiana State University, LA, Baton Rouge, USA.
Chin-Chi LiuVeterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, LA, Baton Rouge, USA.
Andrea JohnstonVeterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, LA, Baton Rouge, USA. johnston1@lsu.edu.
Louisiana State University · USTufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDomestic cats rarely develop hepatocellular carcinoma. The reason for the low prevalence is unknown. Reductions in hepatocellular ploidy have been associated with hepatic carcinogenesis. Recent work in mice has shown that livers with more polyploid hepatocytes are protected against the development of hepatocellular carcinoma. Hepatocyte ploidy in the domestic cat has not been evaluated. We hypothesized that ploidy would be reduced in peri-tumoral and neoplastic hepatocytes compared to normal feline hepatocytes. Using integrated fluorescence microscopy, we quantified the spectra of ploidy in hepatocellular carcinoma and healthy control tissue from paraffin embedded tissue sections.

resultsFeline hepatocytes are predominantly mononuclear and the number of nuclei per hepatocyte did not differ significantly between groups. Normal cats have a greater number of tetraploid hepatocytes than cats with hepatocellular carcinoma.

conclusionsTotal hepatocellular polyploidy in normal cat liver is consistent with values reported in humans, yet cellular ploidy (nuclei per cell) is greater in humans than in cats. Tetraploid cat hepatocytes are predominantly mononuclear.

Indexed as

PloidiesAnimalsCarcinoma, HepatocellularCat DiseasesCatsFemaleHepatocytesLiver NeoplasmsMaleFelineHepatocellular carcinomaLiverPloidy

Identifiers

PMID33663494
PMCPMC7934229
OpenAlexW3016816652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.