SynthesisMalaria journal2021
What is the yield of malaria reactive case detection in the Greater Mekong Sub-region? A review of published data and meta-analysis.
Synthesis in Malaria journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Adapting reactive case detection strategies for high-risk populations to increase malaria infection detection in Aceh Province, Indonesia.PLOS global public health · 2026Article
- Evaluating Thailand's malaria reactive surveillance and response strategies for malaria elimination: a mixed-method study.Infectious diseases of poverty · 2025Article
- Evaluating malaria reactive surveillance and response strategies in northeast Cambodia: a mixed-methods study.Malaria journal · 2025Article
- The contribution of active case detection to malaria elimination in Thailand.BMJ global health · 2023Article
- 1-3-7 surveillance and response approach in malaria elimination: China's practice and global adaptions.Malaria journal · 2023Review
- Reactive Case Detection Strategy for Malaria Control and Elimination: A 12 Year Systematic Review and Meta-Analysis from 25 Malaria-Endemic Countries.Tropical medicine and infectious disease · 2023Review
- Metagenomic Sequencing for the Diagnosis ofInternational journal of molecular sciences · 2022Article
- Limited Reliability of the Molecular Detection ofMicroorganisms · 2022Article
- Clustering of malaria in households in the Greater Mekong Subregion: operational implications for reactive case detection.Malaria journal · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReactive malaria case detection involves the screening of those in contact with index cases and is used in countries in the Greater Mekong Sub-region. The yield of reactive case detection, defined here as the percentage of positive malaria cases among potential contacts who were screened, was assessed.
methodsA literature search was conducted on PubMed to identify studies on reactive case detection in the Greater Mekong Sub-region. Eligible published articles were reviewed and pooled estimates from the studies were calculated, by type of malaria test used.
resultsEighty-five publications were retrieved, of which 8 (9.4%) eligible articles were included in the analysis. The yield from reactive case detection ranged from 0.1 to 4.2%, with higher rates from PCR testing compared with microscopy and/or rapid diagnostic test. The overall yield from microscopy and/or rapid diagnostic test was 0.56% (95% CI 0.31-0.88%), while that from PCR was 2.35% (95% CI 1.19-3.87%). The two studies comparing different target groups showed higher yield from co-workers/co-travellers, compared with household contacts.
conclusionIn low malaria transmission settings, the effectiveness of reactive case detection is diminishing. In the Greater Mekong Sub-region, modifying reactive case detection from household contacts to co-workers/co-travellers and from testing to presumptive treatment of targeted contacts, could increase the impact of this approach.
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