ArticleBMC cancer2021
Prediction of ipsilateral lateral cervical lymph node metastasis in papillary thyroid carcinoma: a combined dual-energy CT and thyroid function indicators study.
Article in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- The role of preoperative serum thyroglobulin in the diagnosis and treatment of differentiated thyroid cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Preoperative Co-Mutation of BRAFCancer medicine · 2026Article
- Dual-layer spectral detector computed tomography multiparameter machine learning model for prediction of lymph node metastases in esophageal squamous cell carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Predictive analysis ofOncology letters · 2026Article
- The combined detection of aspiration biopsy, computed tomography and BRAFV600E gene has high diagnostic value for papillary thyroid carcinoma.Archives of endocrinology and metabolism · 2025Article
- Positive preoperative circulating tumor cells level associated with lymph node metastasis in papillary thyroid carcinoma patients with capsular invasion.World journal of surgical oncology · 2025Article
- The preoperative prediction of lymph node metastasis of resectable pancreatic ductal adenocarcinoma using dual-layer spectral computed tomography.European radiology · 2025Article
- Application and validation of the machine learning-based multimodal radiomics model for preoperative prediction of lateral lymph node metastasis in papillary thyroid carcinoma.Frontiers in endocrinology · 2025Article
- Value of dual-layer spectral detector CT in predicting lymph node metastasis of non-small cell lung cancer.Quantitative imaging in medicine and surgery · 2024Article
- The diagnostic performance of dual-energy CT imaging in cervical lymph node metastasis of papillary thyroid cancer: a meta-analysis.Frontiers in medicine · 2024Review
- Analysis of preoperative computed tomography radiomics and clinical factors for predicting postsurgical recurrence of papillary thyroid carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Cervical lymph node metastasis prediction of postoperative papillary thyroid carcinoma beforeFrontiers in endocrinology · 2023Article
- Gemstone Spectral CT Virtual Noncontrast Images and Iodine Maps for the Characterization of Thyroid Lesions and Distinguishing Thyroid Papillary Carcinoma from Nodular Goiter.International journal of endocrinology · 2023Article
- Diagnosis of benign and malignant thyroid nodules by a dual-layer spectral detector CT-based nomogram.Frontiers in oncology · 2023Article
- Diagnosing cervical lymph node metastasis in oral squamous cell carcinoma based on third-generation dual-source, dual-energy computed tomography.European radiology · 2023Article
- Article
- Ultrasound grayscale ratio: a reliable parameter for differentiating between papillary thyroid microcarcinoma and micronodular goiter.BMC endocrine disorders · 2022Article
- Multiphase Dual-Energy Spectral CT-Based Deep Learning Method for the Noninvasive Prediction of Head and Neck Lymph Nodes Metastasis in Patients With Papillary Thyroid Cancer.Frontiers in oncology · 2022Article
- Dual-Energy Computed Tomography Parameters Combined With Inflammatory Indicators Predict Cervical Lymph Node Metastasis in Papillary Thyroid Cancer.Cancer control : journal of the Moffitt Cancer CenterArticle
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundPredicting the possibility of ipsilateral lateral cervical lymph node metastasis (ipsi-LLNM) was crucial to the operation plan for patients with papillary thyroid carcinoma (PTC). This study aimed to investigate the independent risk factors for ipsi-LLNM in PTC patients by combining dual-energy computed tomography (DECT) with thyroid function indicators.
methodsWe retrospectively enrolled 406 patients with a pathological diagnosis of PTC from Jan 2016 to Dec 2019. Ensure the DECT images were clear and the thyroid function indicators were complete. Univariate and multivariate logistic analyses explored the independent risk factors for ipsi-LLNM. To evaluate the cutoff value of each risk factor by using receiver operating characteristic (ROC) curves.
resultsA total of 406 patients with PTC were analyzed, including 128 with ipsi-LLNM and 278 without ipsi-LLNM. There were statistical differences of parameters between the two groups (P < .0001), including serum Tg, Anti-Tg, Anti-TPO, the volume of the primary lesion, calcification, extrathyroidal extension (ETE), and iodine concentration (IC) in the arterial and the venous phases. Independent risk factors for ipsi-LLNM included serum Tg, Anti-Tg, ETE, and IC in the arterial and the venous phases (P < .05). The combined application of the above independent risk factors can predict the possibility of ipsi-LLNM, with an AUC of 0.834. Ipsi-LLNM was more likely to occur when the following conditions were met: with ETE, Tg > 100.01 ng/mL, Anti-Tg > 89.43 IU/mL, IC in arterial phase > 3.4 mg/mL and IC in venous phase > 3.1 mg/mL.
conclusionsThe combined application of DECT quantitative parameters and thyroid function indicators can help clinicians accurately predict ipsi-LLNM before surgery, thereby assisting the individualized formulation of surgical procedures.
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