Evidence map›Paper›PMID 33663276›Full record

ArticleAIDS care2022

Polysubstance use and adherence to antiretroviral treatment in the Miami Adult Studies on HIV (MASH) cohort.

Abraham Degarege, Karl Krupp, Javier Tamargo, Sabrina Sales Martinez, Adriana Campa, Marianna Baum

Open access · greenAbstract read
In one paragraph

Article in AIDS care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Abraham DegaregeDepartment of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA.
Karl KruppDepartment of Health Promotion Sciences, Mel & Enid Zuckerman College of Public Health, The University of Arizona, Tucson, AZ, USA.
Javier TamargoStempel College of Public Health and Social Work, Florida International University, Miami, FL, USA.ORCID 0000-0001-9385-9049
Sabrina Sales MartinezStempel College of Public Health and Social Work, Florida International University, Miami, FL, USA.
Adriana CampaStempel College of Public Health and Social Work, Florida International University, Miami, FL, USA.
Marianna BaumStempel College of Public Health and Social Work, Florida International University, Miami, FL, USA.
Florida International University · USUniversity of Arizona · USUniversity of Nebraska Medical Center · US

Funding

Community-Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable PopulationsU01DA040381 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI BAUM, MARIANNA K · 2015 to 2022
$9.6M
Alcohol & Antiretrovirals in HIV Infection, Oxidative Stress and Liver DiseaseR01AA018011 · NIAAA · FLORIDA INTERNATIONAL UNIVERSITY · PI BAUM, MARIANNA K · 2008 to 2012
$2.3M
NIAAA NIH HHS R01 AA018011NIDA NIH HHS U01 DA040381
6 · The paper itself

Abstract

Evidence for a relationship between polysubstance use, depression, and adherence to antiretroviral therapy (ART) is limited. The objectives of this study were to examine the associations of depression, illicit drug, and alcohol use with adherence to ART. People living with HIV (PLHIV) from the Miami Adult Studies on HIV cohort were asked about the number of doses of their ART medication missed to assess ART adherence. Harmful alcohol drinking was evaluated using the Alcohol Use Disorders Identification Test and illicit substance use assessed with self-report and urine screen. The Center for Epidemiologic Studies Depression Scale was used to assess depression symptoms. Of 391 PLHIV, 16.6% missed at least one dose (range:1-4) in the past four days. Cocaine/crack, opiate use, and depression were significantly independently associated with a greater mean number of doses missed. The mean number of doses missed was significantly greater among participants who used alcohol in combination with cocaine/crack, marijuana, and tobacco compared to non-users. In conclusion, polysubstance use increased the risk for poor ART adherence among PLHIV. The use of cocaine/crack or opiates individually and depressive symptoms also promote poor ART adherence. An integrated approach targeting substance disorders and depression may help achieve better ART adherence.

Indexed as

AlcoholismAnti-HIV AgentsCrack CocaineHIV InfectionsAdultAnti-Retroviral AgentsHumansMedication AdherenceAnti-HIV AgentsAnti-Retroviral AgentsCrack CocaineARTdepressionHIVMASHPolysubstance

Identifiers

PMID33663276
PMCPMC8418625
OpenAlexW3134154247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.