ArticleNeuroImage. Clinical2021
Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder.
Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Abnormal resting-state functional connectivity in anhedonia: A systematic review and meta-analysis.Brain imaging and behavior · 2026Pooled it
- Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder.Translational psychiatry · 2022Pooled it
- Effects of the KCNQ (Kv7) Channel Opener Ezogabine on Resting-State Functional Connectivity of Striatal Brain Reward Regions, Depression, and Anhedonia in Major Depressive Disorder: Results From a Randomized Controlled Trial.Biological psychiatry · 2025Trial
- Ventral prefrontal network response to alcohol in young adults with bipolar disorder: a within-subject randomized placebo-controlled alcohol administration study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Sex and pubertal stage as moderators of the association between resting-state connectivity of striatal circuitry and reward sensitivity in the Adolescent Brain Cognitive Development study.Developmental cognitive neuroscience · 2026Article
- Reward pursuit during a translational reward task correlates with anhedonia reductions following rTMS in patients with major depressive disorder.Translational psychiatry · 2026Article
- Functional connectivity of the nucleus accumbens and the amygdala in offspring of parents with bipolar or major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Neonatal striatal volume is associated with infant anhedonia.Journal of affective disorders · 2026Article
- Reward circuit function and treatment outcome following vALIC deep brain stimulation in treatment-resistant depression.Molecular psychiatry · 2026Article
- Gestational stress disrupts the neuroimmune environment in the nucleus accumbens of maternal rats.Brain, behavior, & immunity - health · 2025Article
- Shared and unique lifetime stressor characteristics and network connectivity predict adolescent anxiety and depression.bioRxiv : the preprint server for biology · 2025Article
- Predicting antidepressant response via local-global graph neural network and neuroimaging biomarkers.NPJ digital medicine · 2025Article
- Deep brain stimulation modulates directional limbic connectivity in major depressive disorder.Psychological medicine · 2025Article
- Resting-state fMRI reveals altered functional connectivity associated with resilience and susceptibility to chronic social defeat stress in mouse brain.Molecular psychiatry · 2025Article
- Specializations in Amygdalar and Hippocampal Innervation of the Primate Nucleus Accumbens Shell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A Clinically Aligned Murine Model of Electroconvulsive Stimulation Reverses Social Aversion and Displays Fear Memory Impairment After Chronic Social Defeat Stress.bioRxiv : the preprint server for biology · 2025Article
- Aberrant functional connectivity of the dorsolateral prefrontal cortex-nucleus accumbens during naturalistic stimulation in adolescent major depressive disorder.Frontiers in psychiatry · 2025Article
- Altered Brain Functional Connectivity and Neurometabolite Correlations in Orofacial Chronic Pain with Central Sensitization.Journal of pain research · 2025Article
- Investigating low intensity focused ultrasound pulsation in anhedonic depression-A randomized controlled trial.Frontiers in human neuroscience · 2025Article
- Mapping of c-Fos Expression in Rat Brain Sub/Regions Following Chronic Social Isolation: Effective Treatments of Olanzapine, Clozapine or Fluoxetine.Pharmaceuticals (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe nucleus accumbens (NAc) is an important region in reward circuit that has been linked with anhedonia, which is a characteristic symptom of major depressive disorder (MDD). However, the relationship between the functional connectivity of the NAc subregions and anhedonia in MDD patients remains unclear.
methodsWe acquired resting-state functional magnetic resonance imaging (fMRI) scans from fifty-one subjects (23 MDD patients and 28 healthy controls). We assessed subjects' trait anhedonia with the Temporal Experience of Pleasure Scale (TEPS). Seed-based resting-state functional connectivity (rsFC) was conducted for each of the NAc subregions (bilateral core-like and shell-like subdivisions) separately to identify regions whose rsFCs with the NAc subregions were altered in the MDD patients and regions whose rsFCs with the NAc subregions showed different correlates with anhedonia between the MDD patients and the healthy controls.
resultsCompared with the health controls, the MDD patients showed decreased rsFCs of the right NAc core-like subdivision with the left mid-anterior orbital prefrontal cortex and the right inferior parietal lobe as well as decreased rsFC of the left NAc core-like subdivision with the right middle frontal gyrus. Moreover, the severity of anhedonia by the group interaction was significant for the rsFC of the right NAc shell-like subdivision with the subgenual/pregenual anterior cingulate cortex and the rsFC of the right NAc core-like subdivision with the precuneus.
conclusionsWe found that the neural correlates of anhedonia indicated by the rsFCs of the NAc subregions were modulated by depression. The modulation effect was regionally-dependent. These findings enrich our understanding of the neural basis of anhedonia in MDD.
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