Evidence map›Paper›PMID 33662459›Full record

ArticleInternational journal of radiation oncology, biology, physics2021

Multiblock Discriminant Analysis of Integrative

Sang Ho Lee, Gary D Kao, Steven J Feigenberg, Jay F Dorsey, Melissa A Frick, Samuel Jean-Baptiste, Chibueze Z Uche, Keith A Cengel, William P Levin, Abigail T Berman and 3 more

Open access · greenAbstract read
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Delta radiomics: a systematic review.La Radiologia medica · 2021
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Sang Ho LeeDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: SangHo.Lee@pennmedicine.upenn.edu.
Gary D KaoDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Steven J FeigenbergDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Jay F DorseyDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Melissa A FrickDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Samuel Jean-BaptisteDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Chibueze Z UcheDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Keith A CengelDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
William P LevinDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Abigail T BermanDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Charu AggarwalDivision of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Yong FanDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Ying XiaoDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
University of Pennsylvania · US

Funding

NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8M
NRG Oncology NCORP Research Base-BIQSFPUG1CA189867 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI Deborah Watkins Bruner, Lisa A. Kachnic · 2014 to 2026
$140.5M
IROC: Enhancing local enrolling site radiological data capture capabilities for NCTN trialsU24CA180803 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI Thomas J. FitzGerald, MICHAEL V KNOPP · 2014 to 2026
$116.2M
Circulating Tumor Cells Analyses and Molecular Profiling for Patients Receiving Radiation TherapyR01CA201071 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DORSEY, JAY FITZGERALD, KAO, GARY D · 2016 to 2020
$2.2M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
NCI NIH HHS R01 CA201071NCI NIH HHS U10 CA180868NCI NIH HHS U24 CA180803NCI NIH HHS UG1 CA189867NIH HHS S10 OD023495
6 · The paper itself

Abstract

purposeThe main objective of the present study was to integrate

methodsFifty-six patients with stage I NSCLC treated with SBRT underwent

resultsFor predicting pre-SBRT CTCs, DIABLO achieved the best performance with combined pre-SBRT PET radiomics and clinical feature blocks, showing CV AUC of 0.875 (P = .009). For predicting post-SBRT CTCs, DIABLO achieved the best performance with combined post-SBRT CT and delta CT radiomics feature blocks, showing CV AUCs of 0.883 (P = .001). In contrast, all single-block sPLS-DA models could not attain CV AUCs higher than 0.7.

conclusionsMultiblock integration with discriminant analysis of

Indexed as

Neoplastic Cells, CirculatingPositron Emission Tomography Computed TomographyAgedAged, 80 and overArea Under CurveBiomarkers, TumorCarcinoma, Non-Small-Cell LungDiscriminant AnalysisFemaleFluorodeoxyglucose F18HumansLung NeoplasmsMaleMiddle AgedProspective StudiesRadiopharmaceuticalsBiomarkers, TumorFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID33662459
PMCPMC8286285
OpenAlexW3134666836

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.