ArticleThe Senior care pharmacist2021
Avoiding Adverse Drug Withdrawal Events When Stopping Unnecessary Medications According to the STOPPFrail Criteria.
Article in The Senior care pharmacist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Criteria to Report Adverse Drug Withdrawal Events in Clinical Trials: A Systematic Review.Journal of the American Geriatrics Society · 2025Pooled it
- Effectiveness of Patient-Directed Education to Sustain Deprescribing: A Pragmatic Trial.Drugs & aging · 2025Trial
- Direct-to-consumer strategies to promote deprescribing in primary care: a pilot study.BMC primary care · 2022Trial
- Reporting patterns of adverse drug withdrawal events using individual case safety reports in the FAERS and Eudravigilance databases.Exploratory research in clinical and social pharmacy · 2026Article
- Trajectories of Medication Use Prior to Death in US Nursing Home Residents With Dementia.Journal of the American Medical Directors Association · 2026Article
- Article
- Clinical Pharmacology of Heart Failure in Frailty.European cardiology · 2026Review
- Adverse Drug Events Associated with Optimizing Heart Failure Pharmacotherapy in Older Adults with Frailty: A Qualitative Study.CJC open · 2025Article
- Prevalence of heart failure pharmacotherapy utilisation, frailty and adverse drug events among hospitalised adults older than 75 years: a multicentre cross-sectional study.Internal medicine journal · 2025Article
- Perspectives on deprescribing in palliative care.Expert review of clinical pharmacology · 2023Review
- Deprescribing trials: A focus on adverse drug withdrawal events.Journal of the American Geriatrics Society · 2022Article
- Appropriateness of care: from medication reconciliation to deprescribing.Internal and emergency medicine · 2021Article
- Shared Medication PLanning In (SIMPLIfy) Home Hospice: An Educational Program to Enable Goal-Concordant Prescribing In Home Hospice.Journal of pain and symptom management · 2021Article
- Methodological Challenges for Epidemiologic Studies of Deprescribing at the End of Life.Current epidemiology reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
objectiveTo provide clinicians with information about avoiding adverse drug withdrawal events (ADWEs) when discontinuing unnecessary medications as per the STOPPFrail criteria. DATA SOURCES: Searches of MEDLINE (1970-June 2020), the Cochrane Database of Systematic Reviews (through June 2020), Google Scholar (through June 2020). STUDY SELECTION: Reviews and original studies of ADWEs. DATA EXTRACTION: Tapering protocols for specific drugs/ classes from randomized controlled deprescribing trials. DATA SYNTHESIS: Six drug classes were identified as being high risk for physiological ADWEs.
conclusionThe occurrence of ADWEs is rare in comparison to adverse drug reactions in older adults. Few drugs/classes have been reported to have physiological ADWEs with abrupt discontinuation. For these we provide information about tapering protocols and symptom monitoring to avoid ADWEs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.